Exploring the bioactivity of pentacyclic triterpenoids as potential antimycobacterial nutraceutics: Insights through comparative biomolecular modelling
A group of bioactive compounds known as triterpenoids, which are often found in plant
materials, have been tested to possess nutritional and pharmaceutical activity. These plant …
materials, have been tested to possess nutritional and pharmaceutical activity. These plant …
In silico analysis to identify potential antitubercular molecules in Morus alba through virtual screening and molecular dynamics simulations
A major obstacle in the treatment of tuberculosis (TB) is to combat the emerging resistant
strains of its causing agent ie Mycobacterium tuberculosis (MTb). The emergence of …
strains of its causing agent ie Mycobacterium tuberculosis (MTb). The emergence of …
Computational evaluation of phytocompounds for combating drug resistant tuberculosis by multi-targeted therapy
S Sundarrajan, S Lulu, M Arumugam - Journal of molecular modeling, 2015 - Springer
The cell wall of Mycobacterium tuberculosis interacts with the host counterpart during the
pathogenesis of tuberculosis. L-rhamnosyl (L-Rha) residue, a linker connects the …
pathogenesis of tuberculosis. L-rhamnosyl (L-Rha) residue, a linker connects the …
Potential Anti-Mycobacterium tuberculosis Activity of Plant Secondary Metabolites: Insight with Molecular Docking Interactions
Tuberculosis (TB) is a recurrent and progressive disease, with high mortality rates
worldwide. The drug-resistance phenomenon of Mycobacterium tuberculosis is a major …
worldwide. The drug-resistance phenomenon of Mycobacterium tuberculosis is a major …
Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves
A Singh, KN Venugopala, MA Khedr… - Journal of …, 2017 - Taylor & Francis
Buddleja saligna (family Buddlejaceae) is a medicinal plant endemic to South Africa. Two
isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the …
isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the …
Identification of bioactive natural compounds as efficient inhibitors against Mycobacterium tuberculosis protein-targets: a molecular docking and molecular dynamics …
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), imposes a
significantly high morbidity threat to humans in both developed and developing nations. The …
significantly high morbidity threat to humans in both developed and developing nations. The …
Computational investigation of phytochemicals identified from medicinal plant extracts against tuberculosis
Tuberculosis (TB) is still one of the world's most challenging infectious diseases and the
emergence of drug-resistant Mycobacterium tuberculosis poses a significant threat to the …
emergence of drug-resistant Mycobacterium tuberculosis poses a significant threat to the …
[HTML][HTML] Discovery of potent triterpenoid and limonoid compounds targeting Mycobacterium tuberculosis enoyl acyl carrier protein reductase (InhA): An in silico …
Drug resistance remains one of the primary concerns in treating tuberculosis (TB), making it
imperative to find new and effective drug candidates for improved TB treatment. Enoyl acyl …
imperative to find new and effective drug candidates for improved TB treatment. Enoyl acyl …
Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive …
Mycobacterial pathogens present a significant challenge to disease control efforts globally
due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of …
due to their inherent resistance to multiple antibiotics. The rise of drug-resistant strains of …
Ligand-based analysis of the antifungal potential of phytosterols and triterpenes isolated from Cryptostegia grandiflora against Candida auris FKBP12
AB Belarmino, DS de Sousa, CHA Roberto… - Steroids, 2024 - Elsevier
Candida auris, a pathogenic fungus, has posed significant challenges to conventional
medical treatments due to its increasing resistance to antifungal agents. Consequently, due …
medical treatments due to its increasing resistance to antifungal agents. Consequently, due …