The proper maintenance of genetic material is essential for the survival of living organisms.
One of the main safeguards of genome stability is homologous recombination involved in …

DNA damage can arise through various mechanisms such as exogenous sources (UV
radiation) or endogenous sources (replication fork collapse). Damaged DNA poses a …

DNA carries the information necessary for the continuity of life. However, its integrity is
constantly threatened by genotoxic stress exerted by various exogenous and endogenous …

Homologous recombination (HR) depends on the formation of a nucleoprotein filament of
the recombinase Rad51 to scan the genome and invade the homologous sequence used as …

Rad51 recombinase is the central player in homologous recombination, the faithful repair
pathway for double-strand breaks and key event during meiosis. Rad51 forms nucleoprotein …

RAD51 assembly on single-stranded (ss) DNAs is a crucial step in the homology-dependent
repair of DNA damage for genomic stability. The formation of the RAD51 filament is …

Homologous recombination is a key mechanism providing both genome stability and
genetic diversity in all living organisms. Recombinases play a central role in this pathway …

The accurate repair of DNA is critical for genome stability and cancer prevention. DNA
double-strand breaks are one of the most toxic lesions; however, they can be repaired using …

Homology search and strand exchange mediated by Rad51 nucleoprotein filaments are key
steps of the homologous recombination process. In budding yeast, Rad52 is the main …

Oncogene activation during tumorigenesis promotes DNA replication stress (RS), which
subsequently drives the formation of cancer-associated chromosomal rearrangements …