Workgroup report: drinking-water nitrate and health—recent findings and research needs

MH Ward, TM DeKok, P Levallois… - Environmental …, 2005 - ehp.niehs.nih.gov
Human alteration of the nitrogen cycle has resulted in steadily accumulating nitrate in our
water resources. The US maximum contaminant level and World Health Organization …

Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water?

HJM Van Grinsven, MH Ward, N Benjamin… - Environmental …, 2006 - Springer
Several authors have suggested that it is safe to raise the health standard for nitrate in
drinking water, and save money on measures associated with nitrate pollution of drinking …

Drinking water nitrate and human health: an updated review

MH Ward, RR Jones, JD Brender, TM De Kok… - International journal of …, 2018 - mdpi.com
Nitrate levels in our water resources have increased in many areas of the world largely due
to applications of inorganic fertilizer and animal manure in agricultural areas. The regulatory …

When does nitrate become a risk for humans?

DS Powlson, TM Addiscott, N Benjamin… - Journal of …, 2008 - Wiley Online Library
Is nitrate harmful to humans? Are the current limits for nitrate concentration in drinking water
justified by science? There is substantial disagreement among scientists over the …

Human health effects of exposure to nitrate, nitrite, and nitrogen dioxide

JD Brender - Just enough nitrogen: Perspectives on how to get there …, 2020 - Springer
Human exposure to nitrogen (N) pollution via nitrate in food and water and nitrogen oxides
in the ambient air is reviewed. Increased risks of myocardial infarction, respiratory problems …

Health implications of exposure to environmental nitrogenous compounds

TT Mensinga, GJA Speijers, J Meulenbelt - Toxicological reviews, 2003 - Springer
All living systems need nitrogen for the production of complex organic molecules, such as
proteins, nucleic acids, vitamins, hormones and enzymes. Due to the intense use of …

Nitrate in public water supplies and the risk of colon and rectum cancers

AJ De Roos, MH Ward, CF Lynch, KP Cantor - Epidemiology, 2003 - journals.lww.com
Background: Nitrate is a widespread contaminant of drinking water, but its potential health
effects are unclear. In the body, nitrate is reduced to nitrite, which can react with amines and …

Ingested nitrate and nitrite and bladder cancer in Northern New England

KH Barry, RR Jones, KP Cantor, LEB Freeman… - …, 2020 - journals.lww.com
Background: N-nitroso compounds are hypothesized human bladder carcinogens. We
investigated ingestion of N-nitroso compound precursors nitrate and nitrite from drinking …

Health implications of nitrate and nitrite in drinking water: an update on methemoglobinemia occurrence and reproductive and developmental toxicity

AM Fan, VE Steinberg - Regulatory toxicology and pharmacology, 1996 - Elsevier
In 1987, an evaluation of the nitrate drinking water standard was performed with a primary
focus on the effects of nitrate on methemoglobinemia and reproductive/developmental …

Volatile N-nitrosamine formation after intake of nitrate at the ADI level in combination with an amine-rich diet.

IT Vermeer, DM Pachen, JW Dallinga… - Environmental …, 1998 - ehp.niehs.nih.gov
Formation of nitrite from ingested nitrate can result in several adverse health effects and
implies a genotoxic risk as a consequence of endogenous formation of carcinogenic N …