The pleiotropic effects of glucocorticoids in metabolic, developmental, immune and stress
response processes have been extensively investigated; conversely, their roles in …

Glucocorticoids (GCs) are steroid hormones that contribute to the regulation of many
physiological processes, such as inflammation, metabolism and stress response, mainly …

Key points• Glucocorticoids are known to be present in the developing zebrafish embryo but
little is known about their physiological role at this early stage.• The zebrafish embryo …

Cortisol is the primary corticosteroid in teleosts that is released in response to stressor
activation of the hypothalamus-pituitary-interrenal axis. The target tissue action of this …

Glucocorticoids regulate a plethora of physiological processes, and are widely used
clinically as anti-inflammatory drugs. Their effects are mediated by the glucocorticoid …

In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the
canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the …

In zebrafish, ovulated oocytes contain both maternal cortisol and the mRNA for the
glucocorticoid receptor (gr), which is spread as granular structures throughout the ooplasm …

Glucocorticoids (GCs) in utero influence embryonic development with consequent
programmed effects on adult physiology and pathophysiology and altered susceptibility to …

Glucocorticoids (GCs) play important roles in developmental and physiological processes
through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 …

Glucocorticoids regulate a wide range of systems in vertebrate organisms, and their effects
are mediated by the glucocorticoid receptor (GR). The responsiveness to glucocorticoids …