Prolonged wakefulness is associated not only with obvious changes in the way we feel and
perform but also with well-known clinical effects, such as increased susceptibility to seizures …

When subjects become unconscious, there is a characteristic change in the way the cerebral
cortex responds to perturbations, as can be assessed using transcranial magnetic …

Prolonged wakefulness alters cortical excitability, which is essential for proper brain function
and cognition. However, besides prior wakefulness, brain function and cognition are also …

We recorded the electroencephalographic (EEG) responses evoked by transcranial
magnetic stimulation (TMS) during the first rapid eye movement (REM) sleep episode of the …

Consciousness fades during deep nonrapid eye movement (NREM) sleep early in the night,
yet cortical neurons remain active, keep receiving sensory inputs, and can display patterns …

Abstract Study Objectives: Prolonged wakefulness leads to a progressive increase in sleep
pressure, reflected in a global increase in slow wave activity (SWA, 0.5-4.5 Hz) in the sleep …

Subjective sleepiness is part of the system controlling the decision to go to sleep in humans.
Extended periods of waking lead to increased sleepiness, as well as to changes in cortical …

By employing transcranial magnetic stimulation (TMS) in combination with high-density
electroencephalography (EEG), we recently reported that cortical effective connectivity is …

In a recent series of experiments we recorded the electroencephalogram (EEG) response to
a direct cortical stimulation in humans during wakefulness, NREM sleep, REM sleep and …

Thalamic and cortical activities are assumed to be time-locked throughout all vigilance
states. Using simultaneous intracortical and intrathalamic recordings, we demonstrate here …