[PDF][PDF] Human SMARCA5 is continuously required to maintain nucleosome spacing

ML Bomber, J Wang, Q Liu, KR Barnett, HM Layden… - Molecular cell, 2023 - cell.com
Genetic models suggested that SMARCA5 was required for DNA-templated events including
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …

SMARCAD1 is an ATP-dependent histone octamer exchange factor with de novo nucleosome assembly activity

J Markert, K Zhou, K Luger - Science Advances, 2021 - science.org
The adenosine 5′-triphosphate (ATP)–dependent chromatin remodeler SMARCAD1 acts
on nucleosomes during DNA replication, repair, and transcription, but despite its implication …

The ISWI ATPase Smarca5 (Snf2h) is required for proliferation and differentiation of hematopoietic stem and progenitor cells

J Kokavec, T Zikmund, F Savvulidi, V Kulvait… - Stem Cells, 2017 - academic.oup.com
The imitation switch nuclear ATPase Smarca5 (Snf2h) is one of the most conserved
chromatin remodeling factors. It exists in a variety of oligosubunit complexes that move DNA …

[PDF][PDF] Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1

SP Rowbotham, L Barki, A Neves-Costa, F Santos… - Molecular cell, 2011 - cell.com
Epigenetic marks such as posttranslational histone modifications specify the functional
states of underlying DNA sequences, though how they are maintained after their disruption …

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining

A Helfricht, W Wiegant, P Thijssen, A Vertegaal… - Cell cycle, 2013 - Taylor & Francis
The cellular response to ionizing radiation (IR)-induced DNA double-strand breaks (DSBs)
in native chromatin requires a tight coordination between the activities of DNA repair …

Loss of ISWI ATPase SMARCA5 (SNF2H) in acute myeloid leukemia cells inhibits proliferation and chromatid cohesion

T Zikmund, H Paszekova, J Kokavec, P Kerbs… - International journal of …, 2020 - mdpi.com
ISWI chromatin remodeling ATPase SMARCA5 (SNF2H) is a well-known factor for its role in
regulation of DNA access via nucleosome sliding and assembly. SMARCA5 transcriptionally …

Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients

TM Fernando, R Piskol, R Bainer, ES Sokol… - Nature …, 2020 - nature.com
Genomic studies performed in cancer patients and tumor-derived cell lines have identified a
high frequency of alterations in components of the mammalian switch/sucrose non …

Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia

T Stopka, D Zakova, O Fuchs, O Kubrova, J Blafkova… - Leukemia, 2000 - nature.com
We identified a subset of genes involved in chromatin remodeling whose mRNA expression
changes in differentiating mouse erythroleukemia (MEL) cells. We furthermore tested their …

SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

K Kurashima, H Kashiwagi, I Shimomura, A Suzuki… - NAR …, 2020 - academic.oup.com
The SWI/SNF chromatin remodeling complex regulates transcription through the control of
chromatin structure and is increasingly thought to play an important role in human cancer …

SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells

AR Barutcu, BR Lajoie, AJ Fritz, RP McCord… - Genome …, 2016 - genome.cshlp.org
The packaging of DNA into chromatin plays an important role in transcriptional regulation
and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as BRG1), the …