An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches

J Lee, J Jang, SM Park, SR Yang - International Journal of Molecular …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …

Role of Nrf2 and its activators in respiratory diseases

Q Liu, Y Gao, X Ci - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Role of Nrf2 in the pathogenesis of respiratory diseases

K Mizumura, S Maruoka, T Shimizu, Y Gon - Respiratory investigation, 2020 - Elsevier
Nuclear factor erythroid 2-related factor (Nrf) 2 is a transcription factor that integrates cellular
stress signals by directing various transcriptional programs. As an evolutionarily conserved …

[HTML][HTML] Role of Nrf2 in disease: Novel molecular mechanisms and therapeutic approaches–Pulmonary disease/asthma

C Audousset, T McGovern, JG Martin - Frontiers in Physiology, 2021 - frontiersin.org
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a major transcription factor involved in
redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an …

The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury

H Zhao, S Eguchi, A Alam, D Ma - American Journal of …, 2017 - journals.physiology.org
Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor
that upregulates antioxidant response elements (AREs)-mediated expression of antioxidant …

Nrf2 protects against airway disorders

HY Cho, SR Kleeberger - Toxicology and applied pharmacology, 2010 - Elsevier
Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor
that regulates antioxidant response elements (AREs)-mediated expression of antioxidant …

Nrf2 defends the lung from oxidative stress

HY Cho, SP Reddy, SR Kleeberger - Antioxidants & redox signaling, 2006 - liebertpub.com
Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …

Canonical and non-canonical mechanisms of Nrf2 activation

CA Silva-Islas, PD Maldonado - Pharmacological research, 2018 - Elsevier
Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Noblesse Oblige: NRF2 Functions in the Airways

HY Cho, SR Kleeberger - American Journal of Respiratory Cell and …, 2014 - atsjournals.org
The transcription factor, nuclear factor (NF), erythroid-derived 2–related factor 2 (NRF2), was
discovered nearly 2 decades ago. Since then, over 4,000 papers have been published on …

[HTML][HTML] Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

N Mercado, R Thimmulappa, CMR Thomas… - Biochemical and …, 2011 - Elsevier
Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in cellular defence
against oxidative stress by inducing the expression of multiple anti-oxidant genes. However …