Distance from sub-Saharan Africa predicts mutational load in diverse human genomes
The Out-of-Africa (OOA) dispersal∼ 50,000 y ago is characterized by a series of founder
events as modern humans expanded into multiple continents. Population genetics theory …
events as modern humans expanded into multiple continents. Population genetics theory …
The deleterious mutation load is insensitive to recent population history
Human populations have undergone major changes in population size in the past 100,000
years, including recent rapid growth. How these demographic events have affected the …
years, including recent rapid growth. How these demographic events have affected the …
No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans
Non-African populations have experienced size reductions in the time since their split from
West Africans, leading to the hypothesis that natural selection to remove weakly deleterious …
West Africans, leading to the hypothesis that natural selection to remove weakly deleterious …
The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives
Over the past decade, there has been both great interest and confusion about whether
recent demographic events—notably the Out-of-Africa-bottleneck and recent population …
recent demographic events—notably the Out-of-Africa-bottleneck and recent population …
Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of Africa
JF Storz, BA Payseur… - Molecular biology and …, 2004 - academic.oup.com
Abstract The last 50,000–150,000 years of human history have been characterized by rapid
demographic expansions and the colonization of novel environments outside of sub …
demographic expansions and the colonization of novel environments outside of sub …
Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans
TCA Smith, PF Arndt, A Eyre-Walker - PLoS genetics, 2018 - journals.plos.org
It has long been suspected that the rate of mutation varies across the human genome at a
large scale based on the divergence between humans and other species. However, it is now …
large scale based on the divergence between humans and other species. However, it is now …
Signatures of natural selection in the human genome
M Bamshad, SP Wooding - Nature Reviews Genetics, 2003 - nature.com
During their dispersal from Africa, our ancestors were exposed to new environments and
diseases. Those who were better adapted to local conditions passed on their genes …
diseases. Those who were better adapted to local conditions passed on their genes …
Relaxed selection during a recent human expansion
S Peischl, I Dupanloup, A Foucal, M Jomphe, V Bruat… - Genetics, 2018 - academic.oup.com
Peischl et al. explore the way evolutionary forces shape genetic variability in expanding
human populations. Over a few generations of separate evolution... Humans have colonized …
human populations. Over a few generations of separate evolution... Humans have colonized …
Evidence that two main bottleneck events shaped modern human genetic diversity
W Amos, JI Hoffman - … of the Royal Society B: Biological …, 2010 - royalsocietypublishing.org
There is a strong consensus that modern humans originated in Africa and moved out to
colonize the world approximately 50 000 years ago. During the process of expansion …
colonize the world approximately 50 000 years ago. During the process of expansion …
Evidence for hitchhiking of deleterious mutations within the human genome
Deleterious mutations present a significant obstacle to adaptive evolution. Deleterious
mutations can inhibit the spread of linked adaptive mutations through a population; …
mutations can inhibit the spread of linked adaptive mutations through a population; …