Contamination is a potential problem in the study of ancient proteins, either from prior
handling of the sample, laboratory consumables, or cross-sample carryover from mass …

The accumulation of post-translational modifications (PTMs) in proteins throughout the
lifecycle has been studied for decades, particularly more so with the advent of soft-ionization …

RATIONALE Non‐enzymatic deamidation accumulates in aging tissues in vivo and has
been proposed to be potentially useful as a molecular clock. The process continues post …

Rationale Much credence has been given in the paleoproteomic community to glutamine
deamidation as a proxy for the age of proteins derived from fossil and subfossil material, and …

The origins, prevalence and nature of dairying have been long debated by archaeologists.
Within the last decade, new advances in high-resolution mass spectrometry have allowed …

Proteomics methods are being increasingly used to study archaeological and
palaeontological bone, assisting in species identification and phylogenetic studies as well …

The use of glutamine deamidation has been controversially proposed as a means of
measuring relative decay in archeological bones using peptide mass fingerprinting data. If …

Attempts to extend methods for dating archaeological bones beyond that of radiocarbon
dating, such as amino acid racemization, have met with limited success owing to the …

Deamidation of glutamine (Q) and asparagine (N) has been recognized as a marker of
degradation and aging in ancient proteins. Using matrix-assisted laser desorption/ionization …

Peptide mass fingerprinting of bone collagen (ZooMS) has previously been proposed as a
method to calculate the extent of the non-enzymatic degradation of glutamine into glutamic …