n− 3 PUFA and membrane microdomains: a new frontier in bioactive lipid research

DWL Ma, J Seo, KC Switzer, YY Fan… - The Journal of nutritional …, 2004 - Elsevier
In recent years, our understanding of the plasma membrane has changed considerably as
our knowledge of lipid microdomains has expanded. Lipid microdomains include structures …

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

SR Shaikh - The Journal of nutritional biochemistry, 2012 - Elsevier
N-3 polyunsaturated fatty acids (PUFAs) from fish oil exert their functional effects by targeting
multiple mechanisms. One mechanism to emerge in the past decade is the ability of n-3 …

[HTML][HTML] Docosahexaenoic acid alters the size and distribution of cell surface microdomains

RS Chapkin, N Wang, YY Fan, JR Lupton… - Biochimica et Biophysica …, 2008 - Elsevier
We recently generated nutritional data suggesting that chemoprotective dietary n-3
polyunsaturated fatty acids (n-3 PUFA) are capable of displacing acylated proteins from lipid …

Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains

JA Williams, SE Batten, M Harris, BD Rockett… - Biophysical journal, 2012 - cell.com
Omega-3 polyunsaturated fatty acids (n-3 PUFA), enriched in fish oils, are increasingly
recognized to have potential benefits for treating many human afflictions. Despite the …

The nutritional significance of lipid rafts

P Yaqoob - Annual review of nutrition, 2009 - annualreviews.org
The structure, size, stability, and functionality of lipid rafts are still in debate, but recent
techniques allowing direct visualization have characterized them in a wide range of cell …

Roles of polyunsaturated fatty acids, from mediators to membranes

T Harayama, T Shimizu - Journal of lipid research, 2020 - ASBMB
PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding
their precise roles and modes of action remains challenging. PUFAs are precursors for a …

[HTML][HTML] How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems

SR Shaikh, JJ Kinnun, X Leng, JA Williams… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Marine long chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic (EPA) and
docosahexaenoic acid (DHA), are bioactive molecules with clinical applications for the …

Bioactive dietary long-chain fatty acids: emerging mechanisms of action

RS Chapkin, DN McMurray, LA Davidson… - British Journal of …, 2008 - cambridge.org
The plasma membranes of all eukaryotic cells contain heterogeneous self-organising
intrinsically unstable liquid ordered domains or lipid assemblies in which key signal …

Omega-3 fatty acids, lipid rafts, and T cell signaling

TY Hou, DN McMurray, RS Chapkin - European journal of pharmacology, 2016 - Elsevier
Abstract n-3 polyunsaturated fatty acids (PUFA) have been shown in many clinical studies to
attenuate inflammatory responses. Although inflammatory responses are orchestrated by a …

The biochemistry of n-3 polyunsaturated fatty acids* 210

DB Jump - Journal of Biological Chemistry, 2002 - ASBMB
Dietary n-3 polyunsaturated fatty acids (n-3 PUFA) 1 have effects on diverse physiological
processes impacting normal health and chronic disease, such as the regulation of plasma …