Astaxanthin attenuates ferroptosis via Keap1-Nrf2/HO-1 signaling pathways in LPS-induced acute lung injury

L Luo, F Huang, S Zhong, R Ding, J Su, X Li - Life Sciences, 2022 - Elsevier
Ferroptosis is a form of regulated nonapoptotic cell death associated with iron-dependent
lipid peroxidation. Previous studies have shown that ferroptosis is involved in the occurrence …

Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway

S Deng, J Li, L Li, S Lin, Y Yang… - International …, 2023 - spandidos-publications.com
Acute lung injury (ALI) causes high morbidity and mortality rates in critically ill patients, and
there are currently no effective therapeutic drugs. Ferroptosis is a newly discovered mode of …

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

J Li, K Lu, F Sun, S Tan, X Zhang, W Sheng… - Journal of Translational …, 2021 - Springer
Background Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces
uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and …

Astaxanthin alleviated acute lung injury by inhibiting oxidative/nitrative stress and the inflammatory response in mice

J Bi, R Cui, Z Li, C Liu, J Zhang - Biomedicine & Pharmacotherapy, 2017 - Elsevier
The purpose of the present study was to assess the effect of astaxanthin (ASX) treatment on
the acute lung injury (ALI) induced by cecal ligation and puncture (CLP) in mice. Mice were …

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis

P Liu, Y Feng, H Li, X Chen, G Wang, S Xu, Y Li… - Cellular & molecular …, 2020 - Springer
Background Ferroptosis is a newly recognized type of cell death, which is different from
traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis …

Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury

R He, B Liu, R Xiong, B Geng, H Meng, W Lin… - Cell death …, 2022 - nature.com
Itaconate, a metabolite produced during inflammatory macrophage activation, has been
extensively described to be involved in immunoregulation, oxidative stress, and lipid …

Ischemia/reperfusion-activated ferroptosis in the early stage triggers excessive inflammation to aggregate lung injury in rats

X Liu, B Pan, X Wang, J Xu, X Wang, Z Song… - Frontiers in …, 2023 - frontiersin.org
Objective Lung ischemia/reperfusion injury (LIRI) is a clinical syndrome of acute lung injury
that occurs after lung transplantation or remote organ ischemia. Ferroptosis and …

Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway

L Lou, M Wang, J He, S Yang, F Meng… - Frontiers in …, 2023 - frontiersin.org
Acute lung injury (ALI) is a life-threatening disease with high incidence and mortality rates.
Urolithin A (UA) is a pomegranate intestinal flora metabolite with anti-inflammatory …

Uridine alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage

K Lai, C Song, M Gao, Y Deng, Z Lu, N Li… - International journal of …, 2023 - mdpi.com
Uridine metabolism is extensively reported to be involved in combating oxidative stress.
Redox-imbalance-mediated ferroptosis plays a pivotal role in sepsis-induced acute lung …

Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis‐Induced Acute Lung Injury through GSK3β/Keap1‐Nrf2‐GPX4 Pathway

YM Wang, FC Gong, X Qi, YJ Zheng… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Ferroptosis is a nonapoptotic form of programmed cell death, which may be
related to the occurrence and development of sepsis‐induced acute respiratory distress …