Purpose: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC)
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …

Purpose: Microsatellite instability (MSI) is found in 10% to 15% of sporadic colorectal tumors
and is usually caused by defects in DNA mismatch repair (MMR). In 1997, a panel of …

Abstract Context.—Microsatellite instability (MSI) due to defective mismatch repair (MMR)
genes has been reported in the majority of colorectal tumors from patients with hereditary …

Alterations of the length of simple repetitive genomic sequences (microsatellite instability,
MSI) characterize a distinct mechanism of colorectal carcinogenesis. Such MSI has been …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …

Colorectal cancers with DNA mismatch repair (MMR) gene mutations characteristically
display a high rate of replication errors in simple repetitive sequences detectable as …

Background Colorectal tumors caused by failure of the DNA mismatch repair system
commonly show microsatellite instability. Our goals were to compare the performance of two …

Immunohistochemical expression analysis of mismatch repair gene products has been
suggested for the prediction of hereditary nonpolyposis colorectal cancer (HNPCC) carrier …

Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colorectal cancer and in a large number of …

Microsatellite instability (MSI) analysis of colorectal cancers is clinically useful to identify
patients with hereditary nonpolyposis colorectal cancer (HNPCC) caused by germline …