Lactobacillus rhamnosus GG Protects the Epithelial Barrier of Wistar Rats from the Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy

A Orlando, M Linsalata, G Bianco, M Notarnicola… - Nutrients, 2018 - mdpi.com
Celiac disease (CD) is a chronic immune-mediated disorder, characterized by enhanced
paracellular permeability across the intestinal epithelium. The complex system of …

Lactobacillus GG restoration of the gliadin induced epithelial barrier disruption: the role of cellular polyamines

A Orlando, M Linsalata, M Notarnicola, V Tutino… - BMC microbiology, 2014 - Springer
Background Celiac disease is characterized by enhanced intestinal paracellular
permeability due to alterations of function and expression of tight junction (TJ) proteins …

Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats

J Cinova, G De Palma, R Stepankova, O Kofronova… - PloS one, 2011 - journals.plos.org
Background and Aims Celiac disease (CD) is a chronic inflammatory disorder of the small
intestine that is induced by dietary wheat gluten proteins (gliadins) in genetically …

Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology

T Ogita, P Bergamo, F Maurano, R D'Arienzo… - Immunobiology, 2015 - Elsevier
Gut microbiota and probiotic strains play an important role in oral tolerance by modulating
regulatory and effector cell components of the immune system. We have previously …

Protective effects of potential probiotic Lactobacillus rhamnosus (MTCC-5897) fermented whey on reinforcement of intestinal epithelial barrier function in a colitis …

H Kaur, T Gupta, S Kapila, R Kapila - Food & Function, 2021 - pubs.rsc.org
Fermented foods provide essential nutritional components and bioactive molecules that
have beneficial effects on several gastrointestinal disorders. In the present investigation, the …

Lactobacillus GG-fermented milk prevents DSS-induced colitis and regulates intestinal epithelial homeostasis through activation of epidermal growth factor receptor

K Yoda, K Miyazawa, M Hosoda, M Hiramatsu… - European journal of …, 2014 - Springer
Background Fermented milk is considered one of the best sources for efficient consumption
of probiotic strains by hosts to promote good health. The purpose of this study was to …

Protective effect of 1, 25-dihydroxy vitamin D3 on pepsin–trypsin-resistant gliadin-induced tight junction injuries

S Dong, TP Singh, X Wei, H Yao, H Wang - Digestive diseases and …, 2018 - Springer
Background Tight junction (TJ) injuries induced by pepsin–trypsin-resistant gliadin (PT–G)
play an important role in the pathogenesis of celiac disease. Previously, 1, 25-dihydroxy …

Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture

K Lindfors, T Blomqvist, K Juuti-Uusitalo… - Clinical & …, 2008 - academic.oup.com
Wheat gliadin induces severe intestinal symptoms and small-bowel mucosal damage in
coeliac disease patients. At present, the only effective treatment for the disease is a strict life …

A probiotic preparation hydrolyzes gliadin and protects intestinal cells from the toxicity of pro-inflammatory peptides

A Giorgi, R Cerrone, D Capobianco, S Filardo… - Nutrients, 2020 - mdpi.com
Celiac disease (CD) is an autoimmune enteropathy caused by an intolerance to gluten
proteins. It has been hypothesized that probiotic bacteria may exert beneficial effects by …

Beneficial Effects of Lactobacilli Species on Intestinal Homeostasis in Low-Grade Inflammation and Stress Rodent Models and Their Implication in the Modulation of …

C Chamignon, G Mallaret, J Rivière, M Vilotte, S Chadi… - Biomolecules, 2023 - mdpi.com
Intestinal barrier integrity is essential in order to maintain the homeostasis of mucosal
functions and efficient defensive reactions against chemical and microbial challenges. An …