Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y1086, c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity
AP Cardoso, ML Pinto, AT Pinto, MI Oliveira, MT Pinto… - Oncogene, 2014 - nature.com
The interactions between cancer cells and their microenvironment are crucial for malignant
progression, as they modulate invasion-related activities. Tumor-associated macrophages …
progression, as they modulate invasion-related activities. Tumor-associated macrophages …
[HTML][HTML] Matrix metalloproteases as maestros for the dual role of LPS-and IL-10-stimulated macrophages in cancer cell behaviour
AP Cardoso, ML Pinto, AT Pinto, MT Pinto, C Monteiro… - Bmc Cancer, 2015 - Springer
Background The interactions established between macrophages and cancer cells are
largely dependent on instructions from the tumour microenvironment. Macrophages may …
largely dependent on instructions from the tumour microenvironment. Macrophages may …
[HTML][HTML] Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells
W Zhang, L Chen, K Ma, Y Zhao, X Liu, Y Wang, M Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Epidermal growth factor receptor (EGFR) is a target of colon cancer therapy, but the effects
of this therapy on the tumor microenvironment remain poorly understood. Our in vivo studies …
of this therapy on the tumor microenvironment remain poorly understood. Our in vivo studies …
[HTML][HTML] Macrophages, as a promising strategy to targeted treatment for colorectal cancer metastasis in tumor immune microenvironment
Y Zhang, Y Zhao, Q Li, Y Wang - Frontiers in Immunology, 2021 - frontiersin.org
The tumor immune microenvironment plays a vital role in the metastasis of colorectal cancer.
As one of the most important immune cells, macrophages act as phagocytes, patrol the …
As one of the most important immune cells, macrophages act as phagocytes, patrol the …
EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis
DM Hardbower, LA Coburn, M Asim, K Singh, JC Sierra… - Oncogene, 2017 - nature.com
Epidermal growth factor receptor (EGFR) signaling is a known mediator of colorectal
carcinogenesis. Studies have focused on the role of EGFR signaling in epithelial cells …
carcinogenesis. Studies have focused on the role of EGFR signaling in epithelial cells …
[HTML][HTML] NCAM-and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated …
N Takase, Y Koma, N Urakawa, M Nishio, N Arai… - Cancer letters, 2016 - Elsevier
Tumor-associated macrophages (TAMs) have important roles in the angiogenesis and tumor
immunosuppression of various cancers, including esophageal squamous cell carcinomas …
immunosuppression of various cancers, including esophageal squamous cell carcinomas …
[HTML][HTML] GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk …
N Urakawa, S Utsunomiya, M Nishio, M Shigeoka… - Laboratory …, 2015 - Elsevier
Tumor-associated macrophages (TAMs) are known to be involved in the progression,
angiogenesis, and motility of various cancers. We previously reported the association …
angiogenesis, and motility of various cancers. We previously reported the association …
[HTML][HTML] Interaction with neutrophils promotes gastric cancer cell migration and invasion by inducing epithelial-mesenchymal transition
W Zhang, J Gu, J Chen, P Zhang, R Ji… - Oncology …, 2017 - spandidos-publications.com
Emerging evidence has revealed that neutrophils have phenotypic and functional plasticity.
Neutrophils could be polarized towards a pro-tumor phenotype by tumor-derived factors. In …
Neutrophils could be polarized towards a pro-tumor phenotype by tumor-derived factors. In …
[HTML][HTML] Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner
J Xu, Y Yu, X He, N Niu, X Li, R Zhang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Abstract Cyclooxygenase-2 (COX2) and tumor-associated macrophages (TAMs) are
associated with invasion, angiogenesis, and poor prognosis in many human cancers …
associated with invasion, angiogenesis, and poor prognosis in many human cancers …
[HTML][HTML] A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression
H Piao, L Fu, Y Wang, Y Liu, Y Wang, X Meng… - Journal of Experimental …, 2022 - Springer
Background Hypoxia and inflammation tumor microenvironment (TME) play a crucial role in
tumor development and progression. Although increased understanding of TME contributed …
tumor development and progression. Although increased understanding of TME contributed …