Human spinal-cord-like tissues induced from human pluripotent stem cells are typically
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …

Abstract Development of neural tube has been extensively modeled in vitro using human
pluripotent stem cells (hPSCs) that are able to form radially organized cellular structures …

The spinal cord contains more than 20 distinct subclasses of neurons that form well-
organized neural circuits capable of sensing the environment and generating motor …

Tissue organoids are a promising technology that may accelerate development of the
societal and NIH mandate for precision medicine. Here we describe a robust and simple …

Human brain organoids, 3D self-assembled neural tissues derived from pluripotent stem
cells, are important tools for studying human brain development and related disorders …

Cell therapy using induced pluripotent stem cell‐derived neurons is considered a promising
approach to regenerate the injured spinal cord (SC). However, the scar formed at the …

The human nervous system is a highly complex but organized organ. The foundation of its
complexity and organization is laid down during regional patterning of the neural tube, the …

The process of oligodendrogenesis has been relatively well delineated in the rodent brain.
However, it remains unknown whether analogous developmental processes are manifested …

Human pluripotent stem cell (hPSC)-derived neurons provide exciting opportunities for in
vitro modeling of neurological diseases and for advancing drug development and …

Organoids with region-specific architecture could facilitate the repair of injuries of the central
nervous system. Here we show that human astrocytes can be directly reprogrammed into …