Dentatin triggers ROS-mediated apoptosis, G0/G1 cell cycle arrest and release of Th1-related cytokines in colorectal carcinoma cells

AK Zulpa, B Muttiah, KM Vellasamy… - Journal of Taibah …, 2023 - Taylor & Francis
Naturally occurring carbazole alkaloid, Dentatin (DTN), is known to inhibit human cancer cell
lines. However, it's inhibitory and immunomodulatory activities in colorectal carcinoma HCT …

[PDF][PDF] Dentatin exerts anticancer effects on human colon cancer cell lines via cell cycle arrest, autophagy, inhibition of cell migration and JAK/STAT signalling pathway

W Xiong, J Dong, S Kong - J BUON, 2019 - jbuon.com
Purpose: Colon cancer is a malignant disease with significant mortality. In the present study
the anticancer effects of a carbazole alkaloid, Dentatin, were examined against colon cancer …

[HTML][HTML] Diosmin in combination with naringenin enhances apoptosis in colon cancer cells

B Zeya, S Nafees, K Imtiyaz, L Uroog… - Oncology …, 2022 - spandidos-publications.com
Colon cancer is one of the most commonly diagnosed malignancies, which begins as a
polyp and grows to become cancer. Diosmin (DS) and naringenin (NR) are naturally …

[HTML][HTML] Oridonin induces apoptosis in oral squamous cell carcinoma probably through the generation of reactive oxygen species and the p38/JNK MAPK pathway

HN Oh, JH Seo, MH Lee, G Yoon… - International …, 2018 - spandidos-publications.com
The anti-inflammatory effects of oridonin (Ordn) have been well established in previous
studies. However, the apoptotic effects of Ordn on oral cancer cells have not yet been …

Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl‐2, Bcl‐xL, Survivin Downregulation, Caspase‐9, ‐3/7 Activation, and NF‐κB Inhibition

IA Arbab, CY Looi, AB Abdul, FK Cheah… - Evidence‐Based …, 2012 - Wiley Online Library
This study was set to investigate antiproliferative potential of dentatin (a natural coumarin
isolated from Clausena excavata Burm. F) against prostate cancer and to delineate the …

Effects of Tetrandrine on the Apoptosis of Cisplatin-resistant Oral Cancer Cells

CW Chang, C Chen, CW Chang… - Pharmacognosy …, 2023 - journals.sagepub.com
Background Cisplatin, the first-line drug for chemotherapy, often has limited treatment
efficacy because of resistance and cancer recurrence mechanisms. Tetrandrine is a unique …

[HTML][HTML] Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways

P Ovadje, S Ammar, JA Guerrero, JT Arnason… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Dandelion extracts have been studied extensively in recent years for its anti-depressant and
anti-inflammatory activity. Recent work from our lab, with in-vitro systems, shows the anti …

Totarol, a natural diterpenoid, induces selective antitumor activity in SGC-7901 human gastric carcinoma cells by triggering apoptosis, cell cycle disruption and …

T Xu, L Huang, Z Liu, D Ma, G Zhang… - Journal of BU ON …, 2019 - europepmc.org
Purpose Totarol is a plant-derived natural product and has been reported to exhibit
important pharmacological activities. However, the anticancer activity of totarol has not been …

Anticancer Impacts of Terminalia catappa Extract on SW480 Colorectal Neoplasm Cell Line

D Shanehbandi, H Zarredar, M Asadi, V Zafari… - Journal of …, 2021 - Springer
Purpose Colorectal cancer (CRC) is one of the most lethal and prevalent cancers throughout
the world. Despite the remarkable advance in the field, drug resistance still remains as an …

[PDF][PDF] Anti-cancer effect of Datura innoxia P. Mill. Leaf extract in vitro through induction of apoptosis in human Colon Adenocarcinoma and larynx cancer cell lines

C Arulvasu, G Babu, R Manikandan, P Srinivasan… - J Pharm Res, 2010 - academia.edu
Native medicinal plants are traditionally used to prevent and treat a variety of diseases,
including cancer. These herbal preparations alleged to have many biological activities, such …