Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
Exploring biological efficacy of novel benzothiazole linked 2, 5-disubstituted-1, 3, 4-oxadiazole hybrids as efficient α-amylase inhibitors: Synthesis, characterization …
In an effort to explore a class of novel antidiabetic agents, we have made an effort to
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
synergize the α-amylase inhibitory potential of 1, 3-benzothiazole and 1, 3, 4-oxadiazole …
Quantitative structure activity relationship studies of novel hydrazone derivatives as α-amylase inhibitors with index of ideality of correlation
The present manuscript describes the synthesis, α-amylase inhibition, in silico studies and in-
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …
Parsing structural fragments of thiazolidin-4-one based α-amylase inhibitors: A combined approach employing in vitro colorimetric screening and GA-MLR based …
Abstract α-Amylase (EC. 3.2. 1.1) is a ubiquitous digestive endoamylase. The abrupt rise in
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …
Identifications of good and bad structural fragments of hydrazone/2, 5-disubstituted-1, 3, 4-oxadiazole hybrids with correlation intensity index and consensus …
The application of QSAR along with other in silico tools like molecular docking, and
molecular dynamics provide a lot of promise for finding new treatments for life-threatening …
molecular dynamics provide a lot of promise for finding new treatments for life-threatening …
Design of novel benzimidazole derivatives as potential α-amylase inhibitors using QSAR, pharmacokinetics, molecular docking, and molecular dynamics simulation …
In the present study, a quantitative relationship between the biological inhibitory activity of
alpha-amylase and molecular structures of novel benzimidazole derivatives is analyzed in …
alpha-amylase and molecular structures of novel benzimidazole derivatives is analyzed in …
Design and synthesis of 2-amino-4,6-diarylpyrimidine derivatives as potent α-glucosidase and α-amylase inhibitors: structure–activity relationship, in vitro, QSAR …
In the present study, a series of 2-amino-4, 6-diarylpyrimidine derivatives was designed,
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
synthesized, characterized and evaluated for their in vitro α-glucosidase and α-amylase …
SMILES-based QSAR and molecular docking study of xanthone derivatives as α-glucosidase inhibitors
Increasing diabetic population is one of the major health concerns all over the world.
Inhibition of α-glucosidase is a clinically proved and attractive strategy to manage diabetes …
Inhibition of α-glucosidase is a clinically proved and attractive strategy to manage diabetes …
In silico drug discovery of Acetylcholinesterase and Butyrylcholinesterase enzymes inhibitors based on Quantitative Structure-Activity Relationship (QSAR) and drug …
In the last years, in order to achieve a better treatment of Alzheimer's disease (AD), much
focus has been put on the development of cholinesterase (Acetylcholinesterase and …
focus has been put on the development of cholinesterase (Acetylcholinesterase and …
Computational design of novel flavonoid analogues as potential AChE inhibitors: analysis using group-based QSAR, molecular docking and molecular dynamics …
C Vats, JK Dhanjal, S Goyal, N Bharadvaja… - Structural Chemistry, 2015 - Springer
Acetyl cholinesterase (AChE) is an enzyme associated with the loss of cholinergic neurones
in Alzheimer's disease. Acetylcholine is an important neurotransmitter found in the brain and …
in Alzheimer's disease. Acetylcholine is an important neurotransmitter found in the brain and …
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- molecular docking α amylase
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- molecular docking computational design
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