We have discovered that native, neuronal expression of alpha-synuclein (Asyn) inhibits viral
infection, injury, and disease in the central nervous system (CNS). Enveloped RNA viruses …

The protein alpha-synuclein is predominantly expressed in neurons and is associated with
neurodegenerative diseases like Parkinson's disease and dementia with Lewy bodies …

To elucidate the role of α‐synuclein in the pathogenesis of Parkinson's disease, both human
α‐synuclein transgenic mice and targeted overexpression of human α‐synuclein in rat …

Abstract Braak and Del Tredici have proposed that typical Parkinson disease (PD) has its
origins in the olfactory bulb and gastrointestinal tract. However, the role of the olfactory …

Intraneuronal accumulation of misfolded alpha-synuclein in the central and peripheral
nervous systems is strongly linked to Parkinson disease (PD) and other related …

Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD);
however, its role in normal vertebrate physiology has remained unknown. Recent studies …

Several transgenic mouse lines with altered α‐synuclein expression have been developed
that show a variety of Parkinson's disease‐like symptoms without specific loss of …

Introduction Interneuronal propagation of α-synuclein has been demonstrated in a variety of
experimental models and may be involved in disease progression during the course of …

The discovery of the involvement of alpha-synuclein (α-syn) in Parkinson's disease (PD)
pathogenesis has resulted in the development and use of viral vector-mediated α-syn …

Two mutations in α‐synuclein, the main constituent of Lewy bodies, have been identified in
familial Parkinson's disease. We have stereotactically injected lentiviral vectors encoding …