Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

The hypothesis is presented that changes in metal ion homeostatic control, particularly of
redox-active metals such as iron and copper, in specific brain regions, leads to the …

Mounting evidence suggests a central role for transition biometals in the etiopathogenesis of
neurodegenerative diseases (ND). Indeed, while studying the molecular basis for this …

Neurodegenerative disorders are featured by a variety of pathological conditions that share
similar critical processes, such as oxidative stress, free radical activity, proteinaceous …

The equilibrium of metal ions is critical for many physiological functions, particularly in the
central nervous system, where metals are essential for development and maintenance of …

Neurodegenerative diseases of the human brain appear in various forms, resulting in
disorders of movement and coordination, cognitive deterioration and psychiatric …

Metal homeostasis in the central nervous system (CNS) is a crucial component of healthy
brain function, because metals serve as enzymatic cofactors and are key components of …

Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for
several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the …

There has been steadily growing interest in the participation of metal ions (especially, zinc,
copper, and iron) in neurobiological processes, such as the regulation of synaptic …

Neurodegenerative disorders include a variety of pathological conditions, which share
similar critical metabolic processes such as protein aggregation and oxidative stress, both of …