[HTML][HTML] Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma
W Szukala, A Lichawska-Cieslar, R Pietrzycka… - Journal of Experimental …, 2021 - Springer
Background Squamous cell carcinoma (SCC) of the skin is a common form of nonmelanoma
skin cancer. Monocyte chemotactic protein 1-induced protein 1 (MCPIP1), also called …
skin cancer. Monocyte chemotactic protein 1-induced protein 1 (MCPIP1), also called …
MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes
B Bugara, P Konieczny, A Wolnicka-Glubisz… - Journal of …, 2017 - Elsevier
Background Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1), also known
as regnase-1, negatively regulates many cellular processes including the cellular response …
as regnase-1, negatively regulates many cellular processes including the cellular response …
[HTML][HTML] Activity of MCPIP1 RNase in tumor associated processes
K Miekus, J Kotlinowski, A Lichawska-Cieslar… - Journal of Experimental …, 2019 - Springer
The monocyte chemoattractant protein-induced protein (MCPIP) family consists of 4
members (MCPIP1–4) encoded by the ZC3h12A-D genes, which are located at different loci …
members (MCPIP1–4) encoded by the ZC3h12A-D genes, which are located at different loci …
Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation
P Konieczny, A Lichawska-Cieslar… - Journal of Molecular …, 2019 - Springer
Abstract MCPIP1 (Regnase-1, encoded by the ZC3H12A gene) regulates the mRNA stability
of several inflammatory cytokines. Due to the critical role of this RNA endonuclease in the …
of several inflammatory cytokines. Due to the critical role of this RNA endonuclease in the …
MCPIP1 expression positively correlates with melanoma‐specific survival of patients, and its overexpression affects vital intracellular pathways of human melanoma …
I Nowak, AA Brożyna, M Zabłocka… - Molecular …, 2021 - Wiley Online Library
The suppressive activity of monocyte chemoattractant protein 1‐induced protein 1 (MCPIP1)
an inflammation‐related ribonuclease, has been described in a few cancer types but has yet …
an inflammation‐related ribonuclease, has been described in a few cancer types but has yet …
[HTML][HTML] MCPIP1 contributes to clear cell renal cell carcinomas development
J Ligeza, P Marona, N Gach, B Lipert, K Miekus, W Wilk… - Angiogenesis, 2017 - Springer
Monocyte Chemoattractant protein-induced protein 1 (MCPIP1), also known as Regnase-1,
is encoded by the ZC3H12a gene, and it mediates inflammatory processes by regulating the …
is encoded by the ZC3H12a gene, and it mediates inflammatory processes by regulating the …
MCPIP-1, alias Regnase-1, controls epithelial inflammation by posttranscriptional regulation of IL-8 production
Pattern recognition receptors are critical for the detection of invading microorganisms. They
activate multiple pathways that lead to the induction of proinflammatory responses and …
activate multiple pathways that lead to the induction of proinflammatory responses and …
MCPIP1 exogenous overexpression inhibits pathways regulating MYCN oncoprotein stability in neuroblastoma
E Boratyn, I Nowak, M Durbas… - Journal of cellular …, 2017 - Wiley Online Library
The main physiological function of MCPIP1 (regnase‐1) is negative regulation of
inflammation. Moreover, roles of regnase‐1 in apoptosis and differentiation have also been …
inflammation. Moreover, roles of regnase‐1 in apoptosis and differentiation have also been …
The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors
J Gorka, P Marona, O Kwapisz, J Rys, J Jura… - European journal of …, 2020 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer. It is
highly vascularized and largely resistant to traditional chemo-and radiotherapy. Decreases …
highly vascularized and largely resistant to traditional chemo-and radiotherapy. Decreases …
[HTML][HTML] MCPIP1 functions as a safeguard of early embryonic development
A Lichawska-Cieslar, W Szukala, TK Prajsnar… - Scientific Reports, 2023 - nature.com
Monocyte chemoattractant protein-induced protein 1 (MCPIP1), also called Regnase-1, is an
RNase that has been described as a key negative modulator of inflammation. MCPIP1 also …
RNase that has been described as a key negative modulator of inflammation. MCPIP1 also …