Integral membrane proteins are found in all cellular membranes and carry out many of the
functions that are essential to life. The membrane-embedded domains of integral membrane …

Integral membrane proteins are found in all cellular membranes and fulfil many of the
functions that are central to life. A critical step in the biosynthesis of membrane proteins is …

The prediction of protein structure from sequence has been a long-standing goal of
molecular biology. Integral membrane proteins, once abhorred by protein chemists and …

The topology of polytopic membrane proteins is determined by topogenic sequences in the
protein, protein-translocon interactions, and interactions during folding within the protein and …

Integral membrane proteins have parts of their polypeptide backbones embedded in a
phospholipid bilayer. These hydrophobic, membrane-spanning domains are separated by …

1000 JENNINGS the topographical arrangement in the lipid bilayer of integral membrane
polypeptides. The classical approaches to the determination of membrane protein …

Due to the heterogenous lipid environment in which integral membrane proteins are
embedded, they should follow a set of assembly rules, which govern transmembrane protein …

Integral membrane protein biogenesis requires the coordination of several events: accurate
targeting of the nascent chain to the membrane; recognition, orientation and integration of …

Transmembrane domain orientation within some membrane proteins is dependent on
membrane lipid composition. Initial orientation occurs within the translocon, but final …

The current libraries of amino acid sequences of membrane proteins are a valuable
resource for the analysis of elements common to these proteins. Multiple-sequence …