The microenvironment is increasingly recognized to have key roles in cancer, and
biomaterials provide a means to engineer microenvironments both in vitro and in vivo to …

Highlights⿢The tumor microenvironment regulates tumor initiation, progression, and
metastasis.⿢We summarize the use of biomaterials in tumor modeling in vitro.⿢Engineered …

Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …

Tumors are complex tissues that consist of stromal cells, such as fibroblasts, immune cells
and mesenchymal stem cells, as well as non-cellular components, in addition to neoplastic …

The use of biomaterials has substantially contributed to both our understanding of
tumorigenesis and our ability to identify and capture tumour cells in vitro and in vivo. Natural …

Biomaterials offer cancer research the third dimension | Nature Materials Skip to main content
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Most of the anticancer drug candidates entering preclinical trials fail to be approved for
clinical applications. The following are among the main causes of these failures: studying …

Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal
levels of epigenetic factors/proteins and tumor suppressors, reprogram the energy …

The natural microenvironment of tumors is composed of extracellular matrix (ECM), blood
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …