IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

The majority of potent new biologics today are IgG-based molecules that have demonstrated
tissue-targeting specificity with favorable clinical response. Several factors determine the …

The humoral immune response provides specific, long-lived protection against invading
pathogens, via immunoglobulin production and other memory functions. IgG, the most …

The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of
passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn …

M281 is a fully human, anti‐neonatal Fc receptor (FcRn) antibody that inhibits FcRn‐
mediated immunoglobulin G (IgG) recycling to decrease pathogenic IgG while preserving …

Careful regulation of the body's immunoglobulin G (IgG) and albumin concentrations is
necessitated by the importance of their respective functions. As such, the neonatal Fc …

The neonatal fragment crystallizable (Fc) receptor (FcRn) functions as a recycling
mechanism to prevent degradation and extend the half-life of IgG and albumin in the …

The neonatal Fc receptor (FcRn) is a key determinant of IgG homeostasis. It binds to the Fc
domain of IgG in a strictly pH-dependent manner and protects IgG from lysosomal …

Careful regulation of the body's immunoglobulin-G (IgG) and albumin concentrations is
necessitated by the importance of their respective functions. As such, the neonatal Fc …