[HTML][HTML] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
M Thoms, R Buschauer, M Ameismeier, L Koepke… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the current coronavirus disease 2019 (COVID-19) pandemic. A major virulence factor of …
the current coronavirus disease 2019 (COVID-19) pandemic. A major virulence factor of …
[HTML][HTML] SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism
SUMMARY The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a
highly contagious virus that underlies the current COVID-19 pandemic. SARS-CoV-2 is …
highly contagious virus that underlies the current COVID-19 pandemic. SARS-CoV-2 is …
Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion
SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with
host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 …
host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 …
The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression
L Bujanic, O Shevchuk, N von Kügelgen, A Kalinina… - Rna, 2022 - rnajournal.cshlp.org
SARS-CoV-2, responsible for the ongoing global pandemic, must overcome a conundrum
faced by all viruses. To achieve its own replication and spread, it simultaneously depends …
faced by all viruses. To achieve its own replication and spread, it simultaneously depends …
The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression
AS Mendez, M Ly, AM González-Sánchez, E Hartenian… - Cell Reports, 2021 - cell.com
Summary Nonstructural protein 1 (nsp1) is a coronavirus (CoV) virulence factor that restricts
cellular gene expression by inhibiting translation through blocking the mRNA entry channel …
cellular gene expression by inhibiting translation through blocking the mRNA entry channel …
I(nsp1)ecting SARS-CoV-2–ribosome interactions
M Simeoni, T Cavinato, D Rodriguez… - Communications …, 2021 - nature.com
While SARS-CoV-2 is causing modern human history's most serious health crisis and
upending our way of life, clinical and basic research on the virus is advancing rapidly …
upending our way of life, clinical and basic research on the virus is advancing rapidly …
[HTML][HTML] Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA
The causative virus of the COVID-19 pandemic, SARS-CoV-2, uses its nonstructural protein
1 (Nsp1) to suppress cellular, but not viral, protein synthesis through yet unknown …
1 (Nsp1) to suppress cellular, but not viral, protein synthesis through yet unknown …
The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation
A Tidu, A Janvier, L Schaeffer, P Sosnowski, L Kuhn… - Rna, 2021 - rnajournal.cshlp.org
SARS-CoV-2 coronavirus is responsible for the Covid-19 pandemic. In the early phase of
infection, the single-strand positive RNA genome is translated into nonstructural proteins …
infection, the single-strand positive RNA genome is translated into nonstructural proteins …
SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms
C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …
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