Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic
and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms …

The genomic integrity of all living organisms is constantly jeopardized by physical [eg
ultraviolet (UV) light, ionizing radiation] and chemical (eg environmental pollutants …

This introductory article should be viewed as a prologue to the Free Radical Biology &
Medicine Special Issue devoted to the important topic of Oxidatively Damaged DNA and its …

Eukaryotic cells have multiple mechanisms for repairing damaged DNA. 06-methylguanine-
DNA methyltransferase directly reverses some simple alkylation adducts. However, most …

Ultraviolet light (UV) is thought to have had a major impact on the early evolution of life. UV
is absorbed by nucleic acids and produces several types of DNA damage, which interfere …

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from
the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and …

Numerous agents of endogenous and exogenous origin damage DNA in our genome.
There are several DNA‐repair pathways that recognize lesions in DNA and remove them …

Endogenous DNA damage induced by hydrolysis, reactive oxygen species and alkylation
modifies DNA bases and the structure of the DNA duplex. Numerous mechanisms have …

DNA photolyases are highly efficient light-driven DNA repair enzymes which revert the
genomedamaging effects caused by ultraviolet (UV) radiation. These enzymes occur in …

Oxidative damage represents the most significant insult to organisms because of continuous
production of the reactive oxygen species (ROS) in vivo. Oxidative damage in DNA, a critical …