Artificial intelligence-based histopathology image analysis identifies a novel subset of endometrial cancers with distinct genomic features and unfavourable outcome
Endometrial cancer (EC) has four molecular subtypes with strong prognostic value and
therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) …
therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) …
[HTML][HTML] AI-based histopathology image analysis reveals a distinct subset of endometrial cancers
A Darbandsari, H Farahani, M Asadi, M Wiens… - Nature …, 2024 - nature.com
Endometrial cancer (EC) has four molecular subtypes with strong prognostic value and
therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) …
therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) …
[HTML][HTML] The evolving role of morphology in endometrial cancer diagnostics: From histopathology and molecular testing towards integrative data analysis by deep …
S Fremond, VH Koelzer, N Horeweg, T Bosse - Frontiers in Oncology, 2022 - frontiersin.org
Endometrial cancer (EC) diagnostics is evolving into a system in which molecular aspects
are increasingly important. The traditional histological subtype-driven classification has …
are increasingly important. The traditional histological subtype-driven classification has …
The emerging role of molecular pathology in directing the systemic treatment of endometrial cancer
A Jamieson, T Bosse… - Therapeutic advances in …, 2021 - journals.sagepub.com
Following the discovery of the four molecular subtypes of endometrial cancer (EC) by The
Cancer Genome Atlas (TCGA) in 2013, subsequent studies used surrogate markers to …
Cancer Genome Atlas (TCGA) in 2013, subsequent studies used surrogate markers to …
Integration of clinical sequencing and immunohistochemistry for the molecular classification of endometrial carcinoma
E Rios-Doria, A Momeni-Boroujeni, CF Friedman… - Gynecologic …, 2023 - Elsevier
Purpose Using next generation sequencing (NGS), The Cancer Genome Atlas (TCGA)
found that endometrial carcinomas (ECs) fall under one of four molecular subtypes, and a …
found that endometrial carcinomas (ECs) fall under one of four molecular subtypes, and a …
Interpretable deep learning predicts the molecular endometrial cancer classification from H&E images: a combined analysis of the PORTEC randomized clinical trials
S Fremond, S Andani, VH Koelzer - SSRN, 2022 - zora.uzh.ch
Background: Endometrial Cancer (EC) is molecularly classified into the POLE-mutated
(POLE mut), mismatch-repair deficient (MMRd), p53 abnormal (p53abn) and no specific …
(POLE mut), mismatch-repair deficient (MMRd), p53 abnormal (p53abn) and no specific …
[HTML][HTML] Prognostic impact of pathologic features in molecular subgroups of endometrial carcinoma
M Ruscelli, T Maloberti, AG Corradini, F Rosini… - Journal of Personalized …, 2023 - mdpi.com
The molecular characterization of endometrial carcinoma (EC) has recently been included in
the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated …
the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated …
4 Refining pathologic interpretation of endometrial carcinomas: lessons learned from a nationwide study in a new era of molecular classification
Objectives Molecular classification of endometrial carcinoma (EC) enables consistent
classification of tumours and provides valuable prognostic and predictive information …
classification of tumours and provides valuable prognostic and predictive information …
Molecular classification of metastatic and recurrent endometrial endometrioid carcinoma: prognostic relevance among low‐and high‐stage tumours
A McHenry, K Devereaux, E Ryan, S Chow… - …, 2024 - Wiley Online Library
Aims Molecular classification according to The Cancer Genome Atlas (TCGA) improves
endometrial endometrioid carcinoma (EEC) prognostication and has specific treatment …
endometrial endometrioid carcinoma (EEC) prognostication and has specific treatment …
[HTML][HTML] Validation of a one-step genomics-based molecular classifier for endometrial carcinoma in a large Chinese population
N Kang, X Zhang, Z Wang, Y Dai, S Lu, W Su… - … -Research and Practice, 2024 - Elsevier
Objective The aim of this study is to delineate the molecular classification features within
Chinese endometrial cancer (EC) patients and to evaluate the concurrence between two …
Chinese endometrial cancer (EC) patients and to evaluate the concurrence between two …