Neuropathic pain is one of the most debilitating pain conditions, yet no therapeutic strategy
has been really effective for its treatment. Hence, a better understanding of its …

The antineoplastic agent oxaliplatin is a first-line treatment for colorectal cancer. However,
neuropathic pain, characterized by hypersensitivity to cold, emerges soon after treatment. In …

Chemotherapy-induced neuropathy (CIN) is one of the most common complications of
cancer treatment with sensory dysfunctions which frequently include pain. The mechanisms …

Background Cholinergic systems regulate the synaptic transmission resulting in the
contribution of the nociceptive behaviors. Anterior cingulate cortex is a key cortical area to …

Background Donepezil, a cholinesterase inhibitor approved in Alzheimer's disease, has
demonstrated analgesic and preventive effects in animal models of oxaliplatin-induced …

The supraspinal pathophysiology of the painful neuropathy induced by paclitaxel, a
chemotherapeutic agent, is not well understood. The γ-aminobutyric acid (GABA) …

Paclitaxel-treated patients frequently experience chemotherapy-induced peripheral
neuropathy (CIPN) and mood changes, such as anxiety. Layer II/III of the medial prefrontal …

Metamizol (also known as dipyrone or sulpyrine) is one of the non-opioid analgesics
commonly used in clinical practice in the treatment of somatic and visceral pain. Here, our …

Human and animal studies suggest that both traumatic nerve injury and toxic challenge with
chemotherapeutic agents involves the reorganization of neural circuits in the brain …

Background Cholinesterase inhibitors which reach the central nervous system produce pain
relief but are poorly tolerated because of gastrointestinal side effects. Here, the authors …