Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …

Rationale: Clinical studies have shown that Sirt3 (Sirtuin 3) expression declines by 40% by
65 years of age paralleling the increased incidence of hypertension and metabolic …

Significance: Vascular dysfunction plays a key role in the development of arteriosclerosis,
heart disease, and hypertension, which causes one-third of deaths worldwide. Vascular …

Abstract Rationale Sirtuin (SIRT3), a major nicotinamide adenine dinucleotide (NAD+)-
dependent deacetylase in mitochondria, declines with aging and its ablation is associated …

Background Emerging evidence indicates that impaired angiogenesis may contribute to
hypertension‐induced cardiac remodeling. The nicotinamide adenine dinucleotide …

Aims The mechanisms underlying ageing-induced vascular remodelling remain unclear.
This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase …

As a nicotinamide adenine dinucleotide (NAD)+-dependent protein deacetylase, SIRT3 is
highly expressed in tissues with high metabolic turnover and mitochondrial content. It has …

Sirtuin1 (SIRT1), which belongs to a highly conserved family of protein deacetylase, is one
of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including …

Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …

Abstract Sirtuin 3 (SIRT3) a mitochondrial enzyme that plays an important role in energy
homeostasis, cardiac remodeling, and heart failure (HF). The expression of SIRT3 declines …