Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and …
Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …
heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to …
Sirt3 impairment and SOD2 hyperacetylation in vascular oxidative stress and hypertension
AE Dikalova, HA Itani, RR Nazarewicz… - Circulation …, 2017 - Am Heart Assoc
Rationale: Clinical studies have shown that Sirt3 (Sirtuin 3) expression declines by 40% by
65 years of age paralleling the increased incidence of hypertension and metabolic …
65 years of age paralleling the increased incidence of hypertension and metabolic …
Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension
SI Dikalov, AE Dikalova - Antioxidants & redox signaling, 2019 - liebertpub.com
Significance: Vascular dysfunction plays a key role in the development of arteriosclerosis,
heart disease, and hypertension, which causes one-third of deaths worldwide. Vascular …
heart disease, and hypertension, which causes one-third of deaths worldwide. Vascular …
Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia
X He, H Zeng, JX Chen - International journal of cardiology, 2016 - Elsevier
Abstract Rationale Sirtuin (SIRT3), a major nicotinamide adenine dinucleotide (NAD+)-
dependent deacetylase in mitochondria, declines with aging and its ablation is associated …
dependent deacetylase in mitochondria, declines with aging and its ablation is associated …
Sirtuin 3 deficiency accelerates hypertensive cardiac remodeling by impairing angiogenesis
T Wei, G Huang, J Gao, C Huang, M Sun… - Journal of the …, 2017 - Am Heart Assoc
Background Emerging evidence indicates that impaired angiogenesis may contribute to
hypertension‐induced cardiac remodeling. The nicotinamide adenine dinucleotide …
hypertension‐induced cardiac remodeling. The nicotinamide adenine dinucleotide …
Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice
Aims The mechanisms underlying ageing-induced vascular remodelling remain unclear.
This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase …
This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase …
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases
J Wu, Z Zeng, W Zhang, Z Deng, Y Wan… - Free Radical …, 2019 - Taylor & Francis
As a nicotinamide adenine dinucleotide (NAD)+-dependent protein deacetylase, SIRT3 is
highly expressed in tissues with high metabolic turnover and mitochondrial content. It has …
highly expressed in tissues with high metabolic turnover and mitochondrial content. It has …
The role of Sirtuin1 in regulating endothelial function, arterial remodeling and vascular aging
Sirtuin1 (SIRT1), which belongs to a highly conserved family of protein deacetylase, is one
of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including …
of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including …
Sirtuin 1 in endothelial dysfunction and cardiovascular aging
S Ministrini, YM Puspitasari, G Beer, L Liberale… - Frontiers in …, 2021 - frontiersin.org
Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …
nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic …
Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease
X He, H Zeng, JX Chen - Journal of cellular physiology, 2019 - Wiley Online Library
Abstract Sirtuin 3 (SIRT3) a mitochondrial enzyme that plays an important role in energy
homeostasis, cardiac remodeling, and heart failure (HF). The expression of SIRT3 declines …
homeostasis, cardiac remodeling, and heart failure (HF). The expression of SIRT3 declines …
相关搜索
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- vascular inflammation deacetylase sirt3
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- essential hypertension deacetylase sirt3
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- oxidative stress deacetylase sirt3
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