[HTML][HTML] The effect of LPA Thr3888Pro on lipoprotein (a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G> A
R Grüneis, C Lamina, S Di Maio, S Schönherr… - Atherosclerosis, 2022 - Elsevier
Background and aims High lipoprotein (a)[Lp (a)] concentrations are associated with
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the …
increased coronary artery disease (CAD) risk. Lp (a) is regulated mainly genetically by the …
Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease
JF Schachtl-Riess, A Kheirkhah, R Grüneis… - Journal of the American …, 2021 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) concentrations are a major independent risk
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …
A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk
T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
Genetic variants associated with Lp (a) lipoprotein level and coronary disease
R Clarke, JF Peden, JC Hopewell… - … England Journal of …, 2009 - Mass Medical Soc
Background An increased level of Lp (a) lipoprotein has been identified as a risk factor for
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
Comprehensive Analysis of the Genetic Variation in the LPA Gene from Short-Read Sequencing
RO Betschart, G Koliopanos, P Garg, L Guo, M Rossi… - BioMed, 2024 - mdpi.com
Lipoprotein (a)(Lp (a)) is a risk factor for cardiovascular diseases and mainly regulated by
the complex LPA gene. We investigated the types of variation in the LPA gene and their …
the complex LPA gene. We investigated the types of variation in the LPA gene and their …
[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
Lipoprotein (a): resurrected by genetics
F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …
Phenotypic characterization of genetically lowered human lipoprotein (a) levels
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
Multiple QTL influence the serum Lp (a) concentration: a genome-wide linkage screen in the PROCARDIS study
S Barlera, C Specchia, M Farrall, BD Chiodini… - European journal of …, 2007 - nature.com
The serum concentration of lipoprotein Lp (a) is known to be highly heritable and associated
with cardiovascular risk. A genome-wide variance component linkage analysis was …
with cardiovascular risk. A genome-wide variance component linkage analysis was …
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