Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats

T Leonardi, J Vanamala, SS Taddeo… - Experimental …, 2010 - journals.sagepub.com
Epidemiological evidence suggests that a diet abundant in fruits and vegetables may protect
against colon cancer. Bioactive compounds, including flavonoids and limonoids, have been …

Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis

H Nomoto, M Iigo, H Hamada, S Kojima… - Nutrition and …, 2004 - Taylor & Francis
Effects of proanthocyanidin (PA), procyanidin B-2 (B-2), and epigallocatechin gallate
(EGCG) on azoxymethane (AOM)-induced colonic preneoplastic aberrant crypt foci (ACF) …

[HTML][HTML] Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis

CA Warren, KJ Paulhill, LA Davidson, JR Lupton… - The Journal of …, 2009 - Elsevier
The flavonoid quercetin suppresses cell proliferation and enhances apoptosis in vitro. In this
study, we determined whether quercetin protects against colon cancer by regulating the …

Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models

A Au, B Li, W Wang, H Roy, K Koehler, D Birt - Nutrition and cancer, 2006 - Taylor & Francis
The efficacy of dietary apigenin, a dietary flavonoid, in colon cancer prevention was
investigated by evaluating the inhibition of the ornithine decarboxylase (ODC) activity and …

Suppression of colon carcinogenesis by bioactive compounds in grapefruit

J Vanamala, T Leonardi, BS Patil, SS Taddeo… - …, 2006 - academic.oup.com
This study evaluated the hypothesis that untreated and irradiated grapefruit as well as the
isolated citrus compounds naringin and limonin would protect against azoxymethane (AOM) …

Citrus limonoids obacunone and limonin inhibit azoxymethane‐induced colon carcinogenesis in rats

T Tanaka, H Kohno, Y Tsukio, S Honjo, M Tanino… - Biofactors, 2000 - Wiley Online Library
Obacunone and limonin are bitter limonoids in citrus. Their modifying effects on the
development of aberrant crypt foci (ACF), the activity of detoxification enzymes, glutathione S …

Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats

T Kawamori, T Tanaka, A HarÃ, J Yamahara, H Mori - Cancer Research, 1995 - AACR
Modifying effects of dietary exposure of seven naturally occurring products on the
development of colonic aberrant crypt foci (ACF) induced by azoxymethane (AOM) were …

Dietary‐feeding of grape seed extract prevents azoxymethane‐induced colonic aberrant crypt foci formation in fischer 344 rats

B Velmurugan, RP Singh, R Agarwal… - Molecular …, 2010 - Wiley Online Library
Chemoprevention by dietary agents/supplements has emerged as a novel approach to
control various malignancies, including colorectal cancer (CRC). This study assessed …

Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression

MJ Wargovich, A Jimenez, K McKee, VE Steele… - …, 2000 - academic.oup.com
We assessed the effects of 78 potential chemopreventive agents in the F344 rat using two
assays in which the inhibition of carcinogen-induced aberrant crypt foci (ACF) in the colon …

Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats

T Tanaka, H Kohno, R Shimada, S Kagami… - …, 2000 - academic.oup.com
The modifying effects of dietary feeding of a polyisoprenylated benzophenone, garcinol,
isolated from Garcinia indica fruit rind on the development of azoxymethane (AOM)-induced …