Evaluating the promise of inclusion of African ancestry populations in genomics

AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

Diversity and inclusion in genomic research: why the uneven progress?

AR Bentley, S Callier, CN Rotimi - Journal of community genetics, 2017 - Springer
Conducting genomic research in diverse populations has led to numerous advances in our
understanding of human history, biology, and health disparities, in addition to discoveries of …

Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry

MD Kessler, L Yerges-Armstrong, MA Taub… - Nature …, 2016 - nature.com
To characterize the extent and impact of ancestry-related biases in precision genomic
medicine, we use 642 whole-genome sequences from the Consortium on Asthma among …

[HTML][HTML] Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program

AT Khan, SM Gogarten, CP McHugh, AM Stilp, T Sofer… - Cell genomics, 2022 - cell.com
How race, ethnicity, and ancestry are used in genomic research has wide-ranging
implications for how research is translated into clinical care and incorporated into public …

High-depth African genomes inform human migration and health

A Choudhury, S Aron, LR Botigué, D Sengupta… - Nature, 2020 - nature.com
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

The genomic landscape of African populations in health and disease

CN Rotimi, AR Bentley, AP Doumatey… - Human molecular …, 2017 - academic.oup.com
A deeper appreciation of the complex architecture of African genomes is critical to the global
effort to understand human history, biology and differential distribution of disease by …

Next generation disparities in human genomics: concerns and remedies

AC Need, DB Goldstein - Trends in Genetics, 2009 - cell.com
Studies of human genetics, particularly genome-wide association studies (GWAS), have
concentrated heavily on European populations, with individuals of African ancestry rarely …

African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

Importance of including non-European populations in large human genetic studies to enhance precision medicine

D Ju, D Hui, DA Hammond, A Wonkam… - Annual review of …, 2022 - annualreviews.org
One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …

A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome

RA Mathias, MA Taub, CR Gignoux, W Fu… - Nature …, 2016 - nature.com
Abstract The African Diaspora in the Western Hemisphere represents one of the largest
forced migrations in history and had a profound impact on genetic diversity in modern …