Evaluating the promise of inclusion of African ancestry populations in genomics
AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …
known, and the resultant scientific and ethical limitations are becoming increasingly …
Diversity and inclusion in genomic research: why the uneven progress?
AR Bentley, S Callier, CN Rotimi - Journal of community genetics, 2017 - Springer
Conducting genomic research in diverse populations has led to numerous advances in our
understanding of human history, biology, and health disparities, in addition to discoveries of …
understanding of human history, biology, and health disparities, in addition to discoveries of …
Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry
To characterize the extent and impact of ancestry-related biases in precision genomic
medicine, we use 642 whole-genome sequences from the Consortium on Asthma among …
medicine, we use 642 whole-genome sequences from the Consortium on Asthma among …
[HTML][HTML] Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program
How race, ethnicity, and ancestry are used in genomic research has wide-ranging
implications for how research is translated into clinical care and incorporated into public …
implications for how research is translated into clinical care and incorporated into public …
High-depth African genomes inform human migration and health
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …
contain more genetic variation than those from any other continent, yet only a fraction of the …
The genomic landscape of African populations in health and disease
CN Rotimi, AR Bentley, AP Doumatey… - Human molecular …, 2017 - academic.oup.com
A deeper appreciation of the complex architecture of African genomes is critical to the global
effort to understand human history, biology and differential distribution of disease by …
effort to understand human history, biology and differential distribution of disease by …
Next generation disparities in human genomics: concerns and remedies
AC Need, DB Goldstein - Trends in Genetics, 2009 - cell.com
Studies of human genetics, particularly genome-wide association studies (GWAS), have
concentrated heavily on European populations, with individuals of African ancestry rarely …
concentrated heavily on European populations, with individuals of African ancestry rarely …
African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
Importance of including non-European populations in large human genetic studies to enhance precision medicine
One goal of genomic medicine is to uncover an individual's genetic risk for disease, which
generally requires data connecting genotype to phenotype, as done in genome-wide …
generally requires data connecting genotype to phenotype, as done in genome-wide …
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
RA Mathias, MA Taub, CR Gignoux, W Fu… - Nature …, 2016 - nature.com
Abstract The African Diaspora in the Western Hemisphere represents one of the largest
forced migrations in history and had a profound impact on genetic diversity in modern …
forced migrations in history and had a profound impact on genetic diversity in modern …