Adolescence is a time of marked changes in sleep, neuromaturation, and alcohol use. While
there is substantial evidence that alcohol disrupts sleep and that disrupted sleep may play a …

Background Alcohol use is on the rise among women in the United States which is
especially concerning since women who drink have a higher risk of alcohol‐related …

Alcoholism is a third leading preventable cause of death in the United States. One of the
most significant and severe consequences of alcohol use is its effects on sleep. Strong and …

Background Recent reports have demonstrated that binge‐like ethanol (EtOH) drinking
leads to an increase in hypothalamic orexin (OX) signaling and that suppressing this …

Addiction is a chronic relapsing disorder characterized by compulsive drug seeking and
drug taking despite negative consequences. Alcohol abuse and addiction have major social …

Recent studies have implicated the hypocretin/orexinergic system in reward-seeking
behavior. Almorexant, a dual orexin/hypocretin R1 and R2 receptor antagonist, has proven …

The orexin/hypocretin (ORX) system plays a major role in motivation for natural and drug
rewards. In particular, a number of studies have shown that ORX signaling through the …

Adolescence is a sensitive and critical period in brain development where psychiatric
disorders such as anxiety, depression and post-traumatic stress disorder are more likely to …

Consequences of prenatal alcohol exposure (AE) include motor hyperactivity, disrupted
sleep and cognitive deficits. Hypothalamic orexin (ORX)-synthesizing neurons are important …

Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral (LH),
perifornical, and dorsomedial (DMH) hypothalamus. These neurons innervate many regions …