Polysialic acid governs T-cell development by regulating progenitor access to the thymus
PM Drake, CM Stock, JK Nathan… - Proceedings of the …, 2009 - National Acad Sciences
Although the polysialyltransferase ST8Sia IV is expressed in both primary and secondary
human lymphoid organs, its product, polysialic acid (polySia), has been largely overlooked …
human lymphoid organs, its product, polysialic acid (polySia), has been largely overlooked …
Polysialic acid is expressed in human naïve CD4+ T cells and is involved in modulating activation
TM Villanueva-Cabello, LD Gutiérrez-Valenzuela… - …, 2019 - academic.oup.com
The activation of human naïve CD4+ T cells, responsible for orchestrating the immune
response, has been reported to cause increased de novo sialylation and overexpression of …
response, has been reported to cause increased de novo sialylation and overexpression of …
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses
PM Drake, JK Nathan, CM Stock, PV Chang… - The Journal of …, 2008 - journals.aai.org
Polysialic acid (polySia) is a large glycan with restricted expression, typically found attached
to the protein scaffold neural cell adhesion molecule (NCAM). PolySia is best known for its …
to the protein scaffold neural cell adhesion molecule (NCAM). PolySia is best known for its …
Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: role in phagocytosis
NM Stamatos, L Zhang, A Jokilammi, J Finne… - …, 2014 - academic.oup.com
Polysialic acid (polySia) is a unique linear homopolymer of α2, 8-linked sialic acid that has
been studied extensively as a posttranslational modification of neural cell adhesion …
been studied extensively as a posttranslational modification of neural cell adhesion …
Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior
Polysialic acid (PSA) is a post-translational protein modification that is widely expressed
among neural cell types during development. Found predominantly on the neural cell …
among neural cell types during development. Found predominantly on the neural cell …
Polysialic acid in the immune system
TM Villanueva-Cabello… - Frontiers in …, 2022 - frontiersin.org
Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent
biophysical characteristics that when expressed drastically influences the interaction …
biophysical characteristics that when expressed drastically influences the interaction …
ST8SIA4-dependent polysialylation is part of a developmental program required for germ layer formation from human pluripotent stem cells
RP Berger, YH Sun, M Kulik, JK Lee, AV Nairn… - Stem …, 2016 - academic.oup.com
Polysialic acid (PSA) is a carbohydrate polymer of repeating α-2, 8 sialic acid residues that
decorates multiple targets, including neural cell adhesion molecule (NCAM). PST and STX …
decorates multiple targets, including neural cell adhesion molecule (NCAM). PST and STX …
Polysialylation controls immune function of myeloid cells in murine model of pneumococcal pneumonia
Polysialic acid (polySia) is a post-translational modification of a select group of cell-surface
proteins that guides cellular interactions. As the overall impact of changes in expression of …
proteins that guides cellular interactions. As the overall impact of changes in expression of …
Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development
K Angata, V Huckaby, B Ranscht… - … and cellular biology, 2007 - Taylor & Francis
Polysialic acid, which is synthesized by two polysialyltransferases, ST8SiaII and ST8SiaIV,
plays an essential role in brain development by modifying the neural cell adhesion molecule …
plays an essential role in brain development by modifying the neural cell adhesion molecule …
Level and localization of polysialic acid is critical for early peripheral nerve regeneration
J Jungnickel, C Brämer, P Bronzlik… - Molecular and Cellular …, 2009 - Elsevier
PolySia, the most striking post-translational modification of the neural cell adhesion
molecule, is down-regulated during postnatal development. After peripheral nerve lesion …
molecule, is down-regulated during postnatal development. After peripheral nerve lesion …