The problem of mRNA decay in E. coli has recently seen exciting progress, with the
discoveries that key degradation enzymes are associated together in a high molecular …

Metabolic instability is a hallmark property of mRNAs in most if not all organisms and plays
an essential role in facilitating rapid responses to regulatory cues. This article provides a …

The instability of messenger RNA is fundamental to the control of gene expression. In
bacteria, mRNA degradation generally follows an “all-or-none” pattern. This implies that if …

The amount of a messenger RNA available for protein synthesis depends on the efficiency
of its transcription and stability. The mechanisms of degradation that determine the stability …

When Apirion first proposed that mRNA decay in Escherichia coli involves a series of endo-
and exonucleolytic events (2), the general working assumption was that the turnover of …

Polyadenylation contributes to the destabilization of bacterial mRNA. We have investigated
the role of polyadenylation in the degradation of RNA by the purifiedEscherichia coli …

Messenger RNAs in prokaryotes exhibit short half-lives when compared with eukaryotic
mRNAs. Considerable progress has been made during recent years in our understanding of …

Degradation of RNA plays a central role in RNA metabolism. In recent years, our knowledge
of the mechanisms of RNA degradation has increased considerably with discovery of the …

Messenger RNA decay plays an important role in prokaryotic gene expression. The
disparate stabilities of bacterial messages in vivo are a consequence of their differential …

Over the past 15 years considerable progress has been made in understanding the
molecular mechanisms of mRNA decay in both prokaryotes and eukaryotes. Interestingly …