[HTML][HTML] Hyperforin, an anti-inflammatory constituent from St. John's wort, inhibits microsomal prostaglandin E2 synthase-1 and suppresses prostaglandin E2 formation …
A Koeberle, A Rossi, J Bauer, F Dehm… - Frontiers in …, 2011 - frontiersin.org
The acylphloroglucinol hyperforin (Hyp) from St. John's wort possesses anti-inflammatory
and anti-carcinogenic properties which were ascribed among others to the inhibition of 5 …
and anti-carcinogenic properties which were ascribed among others to the inhibition of 5 …
Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense
U Siemoneit, A Koeberle, A Rossi… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Frankincense, the gum resin derived from Boswellia
species, showed anti‐inflammatory efficacy in animal models and in pilot clinical studies …
species, showed anti‐inflammatory efficacy in animal models and in pilot clinical studies …
Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase‐1
A Koeberle, F Pollastro, H Northoff… - British journal of …, 2009 - Wiley Online Library
Background and purpose: The selective inhibition of prostaglandin (PG) E2 formation via
interference with microsomal PGE2 synthase (mPGES)‐1 could have advantages in the …
interference with microsomal PGE2 synthase (mPGES)‐1 could have advantages in the …
Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2 Synthase-1
M Verhoff, S Seitz, M Paul, SM Noha… - Journal of Natural …, 2014 - ACS Publications
The microsomal prostaglandin E2 synthase (mPGES)-1 is the terminal enzyme in the
biosynthesis of prostaglandin (PG) E2 from cyclooxygenase (COX)-derived PGH2. We …
biosynthesis of prostaglandin (PG) E2 from cyclooxygenase (COX)-derived PGH2. We …
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase
D Albert, I Zündorf, T Dingermann, WE Müller… - Biochemical …, 2002 - Elsevier
The acylphloroglucinol derivative hyperforin is the major lipophilic constituent in the herb
Hypericum perforatum (St. John's wort). The aim of the present study was to investigate if …
Hypericum perforatum (St. John's wort). The aim of the present study was to investigate if …
Prostaglandin E2 production and induction of prostaglandin endoperoxide synthase-2 is inhibited in a murine macrophage-like cell line, RAW 264.7, by Mallotus …
R Ishii, M Horie, K Saito, M Arisawa… - Biochimica et Biophysica …, 2002 - Elsevier
An aqueous acetone extract obtained from the pericarps of Mallotus japonicus (MJE) was
observed to inhibit prostaglandin (PG) E2 production in a lipopolysaccharide (LPS) …
observed to inhibit prostaglandin (PG) E2 production in a lipopolysaccharide (LPS) …
Inhibition of Prostaglandin E2 Production by Anti-inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells
KDP Hammer, ML Hillwig, AKS Solco… - Journal of agricultural …, 2007 - ACS Publications
Hypericum perforatum (Hp) is commonly known for its antiviral, antidepressant, and cytotoxic
properties, but traditionally Hp was also used to treat inflammation. In this study, the anti …
properties, but traditionally Hp was also used to treat inflammation. In this study, the anti …
Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol
A Koeberle, H Northoff, O Werz - Biochemical pharmacology, 2009 - Elsevier
Garcinol (camboginol) from the fruit rind of Guttiferae species shows anti-carcinogenic and
anti-inflammatory properties, but the underlying molecular mechanisms are unclear. Here …
anti-inflammatory properties, but the underlying molecular mechanisms are unclear. Here …
[HTML][HTML] Discovery of depsides and depsidones from lichen as potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models
J Bauer, B Waltenberger, SM Noha, D Schuster… - …, 2012 - ncbi.nlm.nih.gov
The major molecular mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is the
inhibition of cyclooxygenases (COX) that leads to suppression of prostanoid formation.[1] …
inhibition of cyclooxygenases (COX) that leads to suppression of prostanoid formation.[1] …
MF63 [2-(6-chloro-1H-phenanthro [9, 10-d] imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in …
D Xu, SE Rowland, P Clark, A Giroux, B Côté… - … of Pharmacology and …, 2008 - ASPET
Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E2 (PGE2)
synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE2 …
synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE2 …