The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
Phosphoinositide 3-kinases as drug targets in cancer
The past two years have seen phosphoinositide 3-kinases (PI3Ks) move from being seen as
potential targets for chemotherapeutics, to one of them—PI3Kα—being generally accepted …
potential targets for chemotherapeutics, to one of them—PI3Kα—being generally accepted …
PI3K-Akt pathway: its functions and alterations in human cancer
M Osaki, M Oshimura, H Ito - Apoptosis, 2004 - Springer
Abstract Phosphatidylinositol-3-kinase (PI3K) is a lipid kinase and generates
phosphatidylinositol-3, 4, 5-trisphosphate (PI (3, 4, 5) P3). PI (3, 4, 5) P3 is a second …
phosphatidylinositol-3, 4, 5-trisphosphate (PI (3, 4, 5) P3). PI (3, 4, 5) P3 is a second …
Should individual PI3 kinase isoforms be targeted in cancer?
Activation of the phosphoinositide-3-kinase (PI3K) signaling pathway is frequently found in
common human cancers, brought about by oncogenic receptor tyrosine kinases (RTKs) …
common human cancers, brought about by oncogenic receptor tyrosine kinases (RTKs) …
The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
A Carnero, JM Paramio - Frontiers in oncology, 2014 - frontiersin.org
When PI3K (phosphatidylinositol-3 kinase) is activated by receptor tyrosine kinases, it
phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase …
phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase …
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications
A Arcaro, AS Guerreiro - Current genomics, 2007 - ingentaconnect.com
The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in human cancer and
represents an attractive target for therapies based on small molecule inhibitors. PI3K …
represents an attractive target for therapies based on small molecule inhibitors. PI3K …
PI3K pathway alterations in cancer: variations on a theme
TL Yuan, LC Cantley - Oncogene, 2008 - nature.com
The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has
led to a surge in the development of PI3K inhibitors. Many of these targeted therapies are …
led to a surge in the development of PI3K inhibitors. Many of these targeted therapies are …
[HTML][HTML] PI3K and AKT: unfaithful partners in cancer
S Faes, O Dormond - International journal of molecular sciences, 2015 - mdpi.com
The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular
processes. An overactivation of the pathway is frequently present in human malignancies …
processes. An overactivation of the pathway is frequently present in human malignancies …
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
LM Thorpe, H Yuzugullu, JJ Zhao - Nature Reviews Cancer, 2015 - nature.com
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …
Targeting phosphoinositide 3-kinase—moving towards therapy
R Marone, V Cmiljanovic, B Giese… - Biochimica et Biophysica …, 2008 - Elsevier
Phosphoinositide 3-kinases (PI3K) orchestrate cell responses including mitogenic signaling,
cell survival and growth, metabolic control, vesicular trafficking, degranulation, cytoskeletal …
cell survival and growth, metabolic control, vesicular trafficking, degranulation, cytoskeletal …