Background: Neuropathy is a prevalent and debilitating complication of poorly managed
diabetes, contributing towards poor quality of life, amputation risk, and increased mortality …

Aims The purpose of this study was to compare the changes of antihyperalgesic
effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late …

Diabetic neuropathy, which affects all peripheral nerves and may cause dramatic pain, is
one of the most severe pathologies associated with hyperglycaemia, damage in the blood …

Diabetic neuropathic pain is a common complication of diabetes mellitus and requires a
substantial amount of societal resources. Pyridoxamine is an inhibitor of advanced glycation …

In view of the pathologic basis for the treatment of diabetic neuropathy, it is important to
enhance nerve regeneration as well as prevent nerve degeneration. So, in the present …

Cizolirtine is a novel non-opioid drug which demonstrated antinociceptive activity in
numerous pain models in rodents. Yet, its mechanism of action remains unknown. Several …

Diabetic peripheral neuropathic pain (DPNP) is a common and intractable complication of
diabetes. Conventional therapies are always not ideal; development of novel drugs is still …

We previously reported that OT-7100 (5-n-butyl-7-(3, 4, 5-trimethoxybenzoylamino) pyrazolo
[1, 5-α] pyrimidine) had antinociceptive potency in various animal models. To further …

Diabetic neuropathy is recognized as one of the most common complications of chronic
diabetes, but its pathophysiological mechanism is complex and yet to be completely …

Objectives: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus.
Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some …