Regulation of in vitro calcium phosphate mineralization by combinatorially selected hydroxyapatite-binding peptides

M Gungormus, H Fong, IW Kim, JS Evans… - …, 2008 - ACS Publications
We report selection and characterization of hydroxyapatite-binding heptapeptides from a
peptide− phage library and demonstrate the effects of two peptides, with different binding …

Phosphorylation-dependent mineral-type specificity for apatite-binding peptide sequences

WN Addison, SJ Miller, J Ramaswamy, A Mansouri… - Biomaterials, 2010 - Elsevier
Apatite-binding peptides discovered by phage display provide an alternative design method
for creating functional biomaterials for bone and tooth tissue repair. A limitation of this …

Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals

WJ Chung, KY Kwon, J Song, SW Lee - Langmuir, 2011 - ACS Publications
The biogenesis of inorganic/organic composite materials such as bone typically involves the
process of templated mineralization. Biomimetic synthesis of bone-like materials therefore …

Synthesis and in vitro hydroxyapatite binding of peptides conjugated to calcium-binding moieties

MB Murphy, JD Hartgerink, A Goepferich… - …, 2007 - ACS Publications
To confer bone-binding properties to proteins and other biological agents that lack specific
targeting capacity, model peptide-based molecules were synthesized containing poly …

Contribution of osteocalcin-mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells

S Hosseini, H Naderi-Manesh, H Vali… - Colloids and Surfaces B …, 2019 - Elsevier
A natural peptide motif in the first helix of osteocalcin (OCN) is used to promote nucleation
and crystallization of hydroxyapatite (HA) in hard tissue. The capability of osteocalcin …

Proteins and their peptide motifs in acellular apatite mineralization of scaffolds for tissue engineering

J Benesch, JF Mano, RL Reis - Tissue Engineering Part B: Reviews, 2008 - liebertpub.com
Many proteins in the inorganic/organic matrix of bone induce or modulate or inhibit
mineralization of apatite in vivo. Many attempts have been made to mimic and understand …

Acidic peptide hydrogel scaffolds enhance calcium phosphate mineral turnover into bone tissue

N Amosi, S Zarzhitsky, E Gilsohn, O Salnikov… - Acta Biomaterialia, 2012 - Elsevier
Designed peptides may generate molecular scaffolds in the form of hydrogels to support
tissue regeneration. We studied the effect of hydrogels comprising β-sheet-forming peptides …

Bioinspired heptapeptides as functionalized mineralization inducers with enhanced hydroxyapatite affinity

Y Liu, C Ding, L He, X Yang, Y Gou, X Xu… - Journal of Materials …, 2018 - pubs.rsc.org
The regeneration of mineral crystals under physiological conditions is an efficient way to
repair defects in hard tissues. To achieve robust mineralization on surfaces such as the tooth …

Self assembled bi-functional peptide hydrogels with biomineralization-directing peptides

M Gungormus, M Branco, H Fong, JP Schneider… - Biomaterials, 2010 - Elsevier
A peptide-based hydrogel has been designed that directs the formation of hydroxyapatite.
MDG1, a twenty-seven residue peptide, undergoes triggered folding to form an …

Identification of a highly specific hydroxyapatite‐binding peptide using phage display

MD Roy, SK Stanley, EJ Amis, ML Becker - Advanced Materials, 2008 - Wiley Online Library
A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is
identified by using a phage display approach. The engineered sequence exhibits chemical …