Regulation of in vitro calcium phosphate mineralization by combinatorially selected hydroxyapatite-binding peptides
M Gungormus, H Fong, IW Kim, JS Evans… - …, 2008 - ACS Publications
We report selection and characterization of hydroxyapatite-binding heptapeptides from a
peptide− phage library and demonstrate the effects of two peptides, with different binding …
peptide− phage library and demonstrate the effects of two peptides, with different binding …
Phosphorylation-dependent mineral-type specificity for apatite-binding peptide sequences
Apatite-binding peptides discovered by phage display provide an alternative design method
for creating functional biomaterials for bone and tooth tissue repair. A limitation of this …
for creating functional biomaterials for bone and tooth tissue repair. A limitation of this …
Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals
The biogenesis of inorganic/organic composite materials such as bone typically involves the
process of templated mineralization. Biomimetic synthesis of bone-like materials therefore …
process of templated mineralization. Biomimetic synthesis of bone-like materials therefore …
Synthesis and in vitro hydroxyapatite binding of peptides conjugated to calcium-binding moieties
MB Murphy, JD Hartgerink, A Goepferich… - …, 2007 - ACS Publications
To confer bone-binding properties to proteins and other biological agents that lack specific
targeting capacity, model peptide-based molecules were synthesized containing poly …
targeting capacity, model peptide-based molecules were synthesized containing poly …
Contribution of osteocalcin-mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells
A natural peptide motif in the first helix of osteocalcin (OCN) is used to promote nucleation
and crystallization of hydroxyapatite (HA) in hard tissue. The capability of osteocalcin …
and crystallization of hydroxyapatite (HA) in hard tissue. The capability of osteocalcin …
Proteins and their peptide motifs in acellular apatite mineralization of scaffolds for tissue engineering
Many proteins in the inorganic/organic matrix of bone induce or modulate or inhibit
mineralization of apatite in vivo. Many attempts have been made to mimic and understand …
mineralization of apatite in vivo. Many attempts have been made to mimic and understand …
Acidic peptide hydrogel scaffolds enhance calcium phosphate mineral turnover into bone tissue
N Amosi, S Zarzhitsky, E Gilsohn, O Salnikov… - Acta Biomaterialia, 2012 - Elsevier
Designed peptides may generate molecular scaffolds in the form of hydrogels to support
tissue regeneration. We studied the effect of hydrogels comprising β-sheet-forming peptides …
tissue regeneration. We studied the effect of hydrogels comprising β-sheet-forming peptides …
Bioinspired heptapeptides as functionalized mineralization inducers with enhanced hydroxyapatite affinity
Y Liu, C Ding, L He, X Yang, Y Gou, X Xu… - Journal of Materials …, 2018 - pubs.rsc.org
The regeneration of mineral crystals under physiological conditions is an efficient way to
repair defects in hard tissues. To achieve robust mineralization on surfaces such as the tooth …
repair defects in hard tissues. To achieve robust mineralization on surfaces such as the tooth …
Self assembled bi-functional peptide hydrogels with biomineralization-directing peptides
M Gungormus, M Branco, H Fong, JP Schneider… - Biomaterials, 2010 - Elsevier
A peptide-based hydrogel has been designed that directs the formation of hydroxyapatite.
MDG1, a twenty-seven residue peptide, undergoes triggered folding to form an …
MDG1, a twenty-seven residue peptide, undergoes triggered folding to form an …
Identification of a highly specific hydroxyapatite‐binding peptide using phage display
MD Roy, SK Stanley, EJ Amis, ML Becker - Advanced Materials, 2008 - Wiley Online Library
A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is
identified by using a phage display approach. The engineered sequence exhibits chemical …
identified by using a phage display approach. The engineered sequence exhibits chemical …