Bromodomain-and extra-terminal domain (BET) proteins are epigenetic reader proteins that
regulate transcription of their target genes by binding to acetylated histone side chains …

Objective. To explore the roles of the bromodomain (Brd) and extra-terminal domain (BET) of
chromatin adaptors in regulating synovial inflammation in RA. Methods. Fibroblast-like …

Bromodomain (BD) and extra-terminal domain containing proteins (BET) are chromatin
adapters that bind acetylated histone marks via two tandem BDs, BD1 and BD2, to regulate …

The reading of acetylation marks on histones by bromodomain (BRD) proteins is a key event
in transcriptional activation. Small molecule inhibitors targeting bromodomain and extra …

Objective To investigate the effects of BET bromodomain protein inhibition on inflammatory
activation and functional properties of rheumatoid arthritis synovial fibroblasts (RASF) …

Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are
involved in the recruitment of additional factors that mediate histone modifications and …

Background: Individual functions of members of the bromodomain (BRD) and extra-terminal
(BET) protein family underlying the anti-inflammatory effects of BET inhibitors in rheumatoid …

Targeting epigenetic reader proteins by small molecule inhibitors represents a new
therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although …

Objective We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis
flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming …

Inflammation is associated with the activation of genes that contribute to immune defense
and tissue repair. The bromodomain-containing proteins of the BET family, which recognize …