Background Many observational epidemiology studies discovered that kidney cancer and
impaired kidney function have a bidirectional relationship. However, it remains unclear …

Background: Results of previous observational studies examining the risk of cancer among
patients with chronic kidney disease (CKD) are conflicting. We here explore the causal …

Objective: Increased cancer risk after dialysis or transplantation has been recognized, but
studies of cancer in pre-dialysis chronic kidney disease (CKD) are extremely limited …

The kidney is a vital organ with diverse biological effects and the burden of kidney function
impairment is increasing in modern medicine. As the effects from kidney function on diverse …

Confounding is major limitation of observational studies. Mendelian randomization (MR) is a
powerful study design that uses genetic variants as instrumental variables to enable …

Background: We evaluated the temporal association between kidney function, assessed by
estimated glomerular filtration rate (eGFR), and the risk of incident renal cell carcinoma …

Patients with chronic renal failure show a greater incidence of malignancies. We evaluated
whether moderately impaired renal function at baseline influenced risk of all cancers during …

Background Several obesity-related factors have been associated with renal cell carcinoma
(RCC), but it is unclear which individual factors directly influence risk. We addressed this …

Chronic kidney disease in its later stages is associated with increased risk of kidney cancer.
We investigated whether chronic kidney disease at milder stages is associated with …

The association between kidney function and cancer incidence is inconsistent among
previous reports, and data on the Japanese population are lacking. It is unknown whether …