[HTML][HTML] Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological …
DV Bradshaw Jr, AK Knutsen, A Korotcov… - Acta Neuropathologica …, 2021 - Springer
Traumatic brain injury (TBI) causes chronic symptoms and increased risk of
neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are …
neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are …
[HTML][HTML] Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury
CM Marion, DP McDaniel, RC Armstrong - Experimental neurology, 2019 - Elsevier
Traumatic brain injury (TBI) often damages axons in white matter tracts and causes corpus
callosum (CC) atrophy in chronic TBI patients. Injured axons encounter irreversible damage …
callosum (CC) atrophy in chronic TBI patients. Injured axons encounter irreversible damage …
Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1
Axonal degeneration is a critical, early event in many acute and chronic neurological
disorders. It has been consistently observed after traumatic brain injury, but whether axon …
disorders. It has been consistently observed after traumatic brain injury, but whether axon …
SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration
Axonal degeneration contributes to the pathogenesis of many neurodegenerative disorders,
motivating efforts to dissect the mechanism of pathological axon loss in order to develop …
motivating efforts to dissect the mechanism of pathological axon loss in order to develop …
Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury
ME Maynard, JB Redell, J Zhao, KN Hood, SM Vita… - Experimental …, 2020 - Elsevier
One of the consistent pathologies associated with both clinical and experimental traumatic
brain injury is axonal injury, especially following mild traumatic brain injury (or concussive …
brain injury is axonal injury, especially following mild traumatic brain injury (or concussive …
[HTML][HTML] Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
Activation of the pro-degenerative protein SARM1 after diverse physical and disease-
relevant injuries causes programmed axon degeneration. Original studies indicate that …
relevant injuries causes programmed axon degeneration. Original studies indicate that …
[HTML][HTML] Multifaceted roles of SARM1 in axon degeneration and signaling
TJ Waller, CA Collins - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Axons are considered to be particularly vulnerable components of the nervous system;
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
impairments to a neuron's axon leads to an effective silencing of a neuron's ability to …
Sarm1-mediated axon degeneration requires both SAM and TIR interactions
J Gerdts, DW Summers, Y Sasaki… - Journal of …, 2013 - Soc Neuroscience
Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or
unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a …
unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a …
[HTML][HTML] SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling
H Liu, J Zhang, X Xu, S Lu, D Yang, C Xie, M Jia… - Theranostics, 2021 - ncbi.nlm.nih.gov
Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …
[HTML][HTML] Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration
W Tian, T Czopka, H López-Schier - Communications biology, 2020 - nature.com
Protecting the nervous system from chronic effects of physical and chemical stress is a
pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for …
pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for …
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