Background T-cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint
inhibitor that has therapeutic implications for many tumors and infectious diseases …

T cell immunoglobulin mucin-3 (Tim-3) is an immune checkpoint inhibitor and its
dysregulation has been related to T cell tolerance and many immune disorders, such as …

T cell Ig and mucin domain (Tim) 3 is a surface molecule expressed throughout the immune
system that can mediate both stimulatory and inhibitory effects. Previous studies have …

Cancer immunotherapy has produced impressive clinical results in recent years. Despite the
success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 …

ABSTRACT T cell Ig mucin-3 (Tim-3), an immune checkpoint inhibitor, shows therapeutic
potential. However, the molecular mechanism by which Tim-3 regulates immune responses …

T cell immunoglobulin and mucin domain protein 3 (Tim‐3) is an immune checkpoint
inhibitor in T cells and innate immune cells. The deregulated upregulation of Tim‐3 is …

T cell immunoglobulin-3 (Tim-3) has been identified as a marker of differentiated interferon-γ-
producing CD4+ T helper type 1 and CD8+ T cytotoxic type 1 cells. The interaction of Tim-3 …

Tim-3, an immune checkpoint inhibitor, is widely expressed on the immune cells and
contributes to immune tolerance. However, the mechanisms by which Tim-3 induces …

T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that
inhibits effector TH1-type responses. Such inhibitory signals prevent unintended tissue …

Over the past decade, cancer immunotherapy, such as immune checkpoint inhibitors (ICRs),
has attained considerable progresses in clinical practice. T-cell immunoglobulin and mucin …