Osteopontin (OPN) is a multifunctional molecule highly expressed in chronic inflammatory
and autoimmune diseases, and it is specifically localized in and around inflammatory cells …

Osteopontin (OPN) was initially identified in osteoblasts as a mineralization-modulatory
matrix protein. Recently, OPN has been studied as a multifunctional protein that is …

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN
is involved in normal physiological processes and is implicated in the pathogenesis of a …

Inflammatory cytokines are necessary for an acute response to injury and the progressive
healing process. However, when this acute response does not resolve and becomes …

Atherosclerosis is a chronic inflammatory process of the vessel wall with systemic correlates.
It is now well established that patients' outcome is tightly linked to atherosclerotic plaque …

Unprecedented advances in secondary prevention have greatly improved the prognosis of
cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally …

Osteopontin (OPN) is a multifunctional protein, and although highly expressed in bone, it is
also expressed by various cell types including macrophages, endothelial cells, smooth …

Osteopontin is a secreted glycoprotein with a multidomain structure and functions
characteristic of a matricellular protein. Osteopontin interacts with cell surface receptors via …

Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of
articular cartilage, inflammation, and changes in periarticular and subchondral bone of …

The secreted phosphorylated protein osteopontin (OPN) is expressed in a variety of tissues
and bodily fluids, and is associated with pathologies including tissue injury, infection …