An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …

We review major modeling strategies and methods to understand and simulate the
macroscopic behavior of mammalian cells. These strategies comprise two important steps …

Mathematical models of the cellular metabolism have a special interest within
biotechnology. Many different kinds of commercially important products are derived from the …

Highlights•Constraint-based models are useful but do not always sufficiently answer a
question.•Kinetic models provide deeper insight into behavior of complex metabolic …

During the last decade, a new generation of high-performance, computerized bioreactors,
on-line monitoring devices for medium components, and techniques for continuous analysis …

Various high-throughput experimental techniques are routinely used for generating large
amounts of omics data. In parallel, in silico modelling and simulation approaches are being …

Analytical approaches for a comprehensive understanding of the metabolic networks in
microbial cultures are mostly based on small-scale cultures which are in a steady state or …

This book is based on a 1981 German language edition published by Springer Verlag,
Vienna, under the title Bioprozesstechnik. Philip Manor has done the translation, for which I …

The complexity of the regulatory network and the interactions that occur in the intracellular
environment of microorganisms highlight the importance in developing tractable mechanistic …

The aim of this paper is to present a systematic methodology to design macroscopic
bioreaction models for cell cultures based upon metabolic networks. The cell culture is seen …