Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with
hyperalgesia and has been proposed to be a cellular mechanism of pain amplification in …

Chronic pain is a major problem since it is difficult to treat and the understanding of the
underlying neurobiology is sparse. The mechanisms underpinning the transition of acute …

Long-term potentiation (LTP) at synapses of nociceptive nerve fibres is a proposed cellular
mechanism underlying some forms of hyperalgesia. In this review fundamental properties of …

Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle
features with hyperalgesia including induction protocols, pharmacological profile, neuronal …

Long-term potentiation (LTP), referring to a lasting increase in efficacy of synaptic
transmission, is a common mechanism of memory storage in central nervous system (CNS) …

Electrical high-frequency stimulation (HFS) of skin afferents elicits long-term potentiation
(LTP)-like hyperalgesia in humans. Time courses were evaluated in the facilitating …

Inflammatory diseases and neuropathic insults trigger signaling cascades, which frequently
lead to intense and long-lasting pain syndromes in affected patients. Such pain syndromes …

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength are
ubiquitous mechanisms of synaptic plasticity, but their functional relevance in humans …

Opioids remain the mainstay of treatment for severe pain, but the associated hyperalgesia
and tolerance are significant impediments to achieving adequate pain relief with opioids …

As in neocortex and hippocampus, neurons in the dorsal horn of the spinal cord develop
long-term potentiation of synaptic efficacy (LTP) on high-frequency stimulation (HFS) of their …