Gut bacterial β-glucuronidase (GUS) can reactivate xenobiotics that exert enterohepatic
circulation-triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced …

Gut bacterial β-glucuronidases (GUS) play an important role in deconjugation of various O-
glucuronides, which are tightly linked with the drug-induced intestinal toxicity. Increasing …

Intestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of
various glucuronides into free aglycone, have been recognized as key targets for treating …

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential
therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal …

Bacterial β-glucuronidases play key roles in the deconjugation of a variety of endogenous
and drug glucuronides, thus have been recognized as important targets to modulate the …

Gut microbial β-glucuronidases (gmβ-GUS) played crucial roles in regulating a variety of
endogenous substances and xenobiotics on the circulating level, thus had been recognized …

Gut microbial β-glucuronidases (GUSs) inhibition is a new approach for managing some
diseases and medication therapy. However, the structural and functional complexity of GUSs …

Phloroglucinols—one of the major secondary metabolites in Dryopteris crassirhizoma—
exhibit various pharmacological effects, such as antiviral, antioxidant, and antidiabetic …

Gut microbial β-glucuronidase (GUS) is a potential therapeutic target to reduce
gastrointestinal toxicity caused by irinotecan. In this study, the inhibitory effects of 17 natural …

Gut microbial β-glucuronidases show varied substrate specificity and inhibition propensity,
highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet …