Abstract Src homology-2 (SH2) domain-containing phosphatases (Shps) are a small, highly
conserved subfamily of protein-tyrosine phosphatases, members of which are present in …

SHP‐2 is a cytoplasmic protein tyrosine phosphatase (PTP) that contains two Src homology
2 (SH2) domains. Although PTPs are generally considered to be negative regulators on the …

Mutations in the Src homology 2 (SH2)-containing protein-tyrosine phosphatase Shp2
(PTPN11) underlie half of the cases of the autosomal dominant genetic disorder Noonan …

Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the
human PTPN11 gene, is a ubiquitously expressed protein tyrosine phosphatase (PTP) that …

The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2) is a
critical signal transducer downstream of growth factors that promotes the activation of the …

SHP-2 protein tyrosine phosphatase plays an important role in activation of the RAS-
dependent signaling. Gain-of-function mutations in the PTPN11 gene, which encodes SHP …

Deregulation of signaling pathways, through mutation or other molecular changes, can
ultimately result in disease. The tyrosine phosphatase Shp2 has emerged as a major …

Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been …

Shp2 is a cytoplasmic protein-tyrosine phosphatase that is essential for normal
development. Activating and inactivating mutations have been identified in humans to cause …

Diverse cellular processes are regulated by tyrosyl phosphorylation, which is controlled by
protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). De-regulated …