During embryonic development, hierarchical cascades of transcription factors interact with
lineage-specific chromatin structures to control the sequential steps in the differentiation of …

The auditory organ of Corti is comprised of only two major cell types—the mechanosensory
hair cells and their associated supporting cells—both specified from a single pool of …

Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In
murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis …

Sensory hair cells are exquisitely sensitive vertebrate mechanoreceptors that mediate the
senses of hearing and balance. Understanding the factors that regulate the development of …

Mechanosensory hair cells (HCs) are the primary receptors of our senses of hearing and
balance. Elucidation of the transcriptional networks regulating HC fate determination and …

Hair cells detect sound, head position or water movements when their mechanosensory hair
bundle is deflected. Each hair bundle has an asymmetric architecture that restricts stimulus …

Hair cells are sensory receptors for the auditory and vestibular system in vertebrates. The
transcription factor Atoh1 is both necessary and sufficient for the differentiation of hair cells …

Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-
helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of …

During epithelial tissue morphogenesis, developmental progenitor cells undergo dynamic
adhesive and cytoskeletal remodeling to trigger proliferation and migration. Transcriptional …

Transcription factors (TFs) can regulate different sets of genes to determine specific cell
types by means of combinatorial codes. We previously identified closely-spaced TF binding …