Background and aims Vascular calcification (VC) is an intricate active process, significantly
controlled by vascular smooth muscle cells (VSMCs). Mitochondrial dysfunction plays a …

Abstract Background/Aims: Vascular calcification, which involves an active cellular
transformation of vascular smooth muscle cells into bone forming cells, is prevalent and …

Irisin protects the cardiovascular system against vascular diseases. However, its role in
chronic kidney disease (CKD)-associated vascular calcification (VC) and the underlying …

Advanced glycation end products (AGEs) accumulate in the bone tissue of patients with
diabetes mellitus, resulting in oxidative stress, poor bone healing, or regeneration. Irisin, a …

Aims Several recent reports have shown irisin protects the heart against
ischemia/reperfusion injury. However, the effect of irisin on I/R injury in diabetic mice has not …

Vascular remodeling plays a vital role in hypertensive diseases and is an important target for
hypertension treatment. Irisin, a newly discovered myokine and adipokine, has been found …

Vascular calcification is a common phenomenon in older adults. Intermedin (IMD) is a
cardiovascular bioactive peptide inhibiting vascular calcification. In this study, we aimed to …

Many studies have highlighted the importance of moderate exercise. While it can attenuate
diabetic kidney disease, its mechanism has remained unclear. The level of myokine irisin in …

Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity,
accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type …

A well-recognized risk factor for periodontitis, diabetes mellitus (DM) aggravates periodontal
disease with increasing alveolar bone loss. As a novel myokine, irisin is closely linked with …